COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021
| العنوان: | COVID-19 Outbreak Associated with a SARS-CoV-2 R.1 Lineage Variant in a Skilled Nursing Facility After Vaccination Program — Kentucky, March 2021 |
|---|---|
| المؤلفون: | Vaneet Arora, Kevin B. Spicer, Douglas Thoroughman, Karim George, Stephanie Lunn, Sarah Fortier, Alyson M. Cavanaugh, Joshua Tobias, Patricia Lewis, Matt Johnson, Taylor Miller |
| المصدر: | Morbidity and Mortality Weekly Report |
| بيانات النشر: | Centers for Disease Control MMWR Office, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, COVID-19 Vaccines, Health (social science), Epidemiology, Health, Toxicology and Mutagenesis, Kentucky, 01 natural sciences, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Health Information Management, Internal medicine, Health care, Humans, Medicine, Infection control, Full Report, 030212 general & internal medicine, 0101 mathematics, Aged, Skilled Nursing Facilities, Immunization Programs, SARS-CoV-2, business.industry, Transmission (medicine), Public health, 010102 general mathematics, COVID-19, Outbreak, General Medicine, Clinical trial, Vaccination, business, Health department |
| الوصف: | Although COVID-19 mRNA vaccines demonstrated high efficacy in clinical trials (1), they were not 100% efficacious. Thus, some infections postvaccination are expected. Limited data are available on effectiveness in skilled nursing facilities (SNFs) and against emerging variants. The Kentucky Department for Public Health (KDPH) and a local health department investigated a COVID-19 outbreak in a SNF that occurred after all residents and health care personnel (HCP) had been offered vaccination. Among 83 residents and 116 HCP, 75 (90.4%) and 61 (52.6%), respectively, received 2 vaccine doses. Twenty-six residents and 20 HCP received positive test results for SARS-CoV-2, the virus that causes COVID-19, including 18 residents and four HCP who had received their second vaccine dose >14 days before the outbreak began. An R.1 lineage variant was detected with whole genome sequencing (WGS). Although the R.1 variant has multiple spike protein mutations, vaccinated residents and HCP were 87% less likely to have symptomatic COVID-19 compared with those who were unvaccinated. Vaccination of SNF populations, including HCP, is critical to reduce the risk for SARS-CoV-2 introduction, transmission, and severe outcomes in SNFs. An ongoing focus on infection prevention and control practices is also essential. |
| تدمد: | 1545-861X 0149-2195 |
| DOI: | 10.15585/mmwr.mm7017e2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d7fdf38e5921a0b44704ed4586b54e https://doi.org/10.15585/mmwr.mm7017e2 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....54d7fdf38e5921a0b44704ed4586b54e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1545861X 01492195 |
|---|---|
| DOI: | 10.15585/mmwr.mm7017e2 |