Cervical cytology in serous and endometrioid endometrial cancer
| العنوان: | Cervical cytology in serous and endometrioid endometrial cancer |
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| المؤلفون: | Saskia F. Zomer, Albert G. Siebers, Thijs Roelofsen, Johan Bulten, Leon F.A.G. Massuger, Yvette P. Geels, Marc P.M.L. Snijders, Johanna M.A. Pijnenborg, Maaike A.P.C. van Ham, Johanna M. Wiersma van Tilburg |
| المصدر: | International Journal of Gynecological Pathology, 32, 4, pp. 390-8 International Journal of Gynecological Pathology, 32, 390-8 |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Pathology, medicine.medical_specialty, Disease, Aetiology, screening and detection [ONCOL 5], Cervix Uteri, Pathology and Forensic Medicine, Cohort Studies, Translational research [ONCOL 3], Carcinoma, Medicine, Humans, Prospective Studies, Cystadenocarcinoma, Prospective cohort study, Aged, Netherlands, Proportional Hazards Models, Gynecology, Aged, 80 and over, Vaginal Smears, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Proportional hazards model, Endometrial cancer, Obstetrics and Gynecology, Middle Aged, medicine.disease, Prognosis, Aetiology, screening and detection Immune Regulation [ONCOL 5], Cystadenocarcinoma, Serous, Endometrial Neoplasms, Serous fluid, stomatognathic diseases, Uterine Neoplasms, Cystadenocarcinoma, Papillary, Female, business, Carcinoma, Endometrioid, Cohort study, Follow-Up Studies |
| الوصف: | Contains fulltext : 118118.pdf (Publisher’s version ) (Closed access) The aim of this study was to determine the frequency of abnormal cervical cytology in preoperative cervical cytology of patients diagnosed with uterine papillary serous carcinoma (UPSC) and endometrioid endometrial carcinoma (EEC). In addition, associations between abnormal cervical cytology and clinicopathologic factors were evaluated. In this multicentre study, EEC patients diagnosed at two hospitals from 1999 to 2009 and UPSC patients diagnosed at five hospitals from 1992 to 2009, were included. Revision of the histologic slides was performed systematically and independently by 3 gynecopathologists. Cervical cytology within six months before histopathologic diagnosis of endometrial carcinoma was available for 267 EEC and 80 UPSC patients. Cervical cytology with atypical, malignant, or normal endometrial cells in postmenopausal women was considered as abnormal cytology, specific for endometrial pathology. Abnormal cervical cytology was found in 87.5% of UPSC patients, compared with 37.8% in EEC patients. In UPSC, abnormal cytology was associated with extrauterine spread of disease (P=0.043). In EEC, abnormal cytology was associated with cervical involvement (P=0.034). In both EEC and UPSC patients, abnormal cervical cytology was not associated with survival. In conclusion, abnormal cervical cytology was more frequently found in UPSC patients. It was associated with extrauterine disease in UPSC patients, and with cervical involvement in EEC patients. More prospective research should be performed to assess the true clinical value of preoperative cervical cytology in endometrial cancer patients. |
| وصف الملف: | application/pdf |
| تدمد: | 0277-1691 |
| DOI: | 10.1097/PGP.0b013e31826a62bb |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c8c4c0052670f96286288c5ee2ea97 https://doi.org/10.1097/PGP.0b013e31826a62bb |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....54c8c4c0052670f96286288c5ee2ea97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02771691 |
|---|---|
| DOI: | 10.1097/PGP.0b013e31826a62bb |