التفاصيل البيبلوغرافية
| العنوان: |
Polypyrrole-incorporated conductive hyaluronic acid hydrogels |
| المؤلفون: |
Goeun Choe, Jae Young Lee, Jongcheol Yang, Sumi Yang, Hyerim Jo |
| المصدر: |
Biomaterials Research |
| بيانات النشر: |
Springer Nature |
| مصطلحات موضوعية: |
Materials science, Scanning electron microscope, Biomedical Engineering, Medicine (miscellaneous), Nanotechnology, 02 engineering and technology, macromolecular substances, 010402 general chemistry, Polypyrrole, Electrochemistry, 01 natural sciences, complex mixtures, Biomaterials, chemistry.chemical_compound, Tissue engineering, Polymer chemistry, Hyaluronic Acid, Conductive, Electrical conductor, technology, industry, and agriculture, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Hydrogel, chemistry, Polymerization, Drug delivery, Self-healing hydrogels, Ceramics and Composites, 0210 nano-technology, Research Article |
| الوصف: |
Background Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. Method To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties. Results Various characterization methods, using a rheometer, a scanning electron microscope, and an electrochemical analyzer, revealed that the PPy/HA hydrogels were soft and conductive with ~ 3 kPa Young’s modulus and ~ 7.3 mS/cm conductivity. Our preliminary in vitro culture studies showed that fibroblasts were well attached and grew on the conductive hydrogels. Conclusion These new conductive hydrogels will be greatly beneficial in fields of biomaterials in which electrical properties are important such as tissue engineering scaffolds and prosthetic devices. |
| اللغة: |
English |
| تدمد: |
2055-7124 |
| DOI: |
10.1186/s40824-016-0078-y |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543ca7051ab51c2c271f3c902084a211 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....543ca7051ab51c2c271f3c902084a211 |
| قاعدة البيانات: |
OpenAIRE |