Increased Irisin Concentrations in Patients with Crimean-Congo Hemorrhagic Fever
| العنوان: | Increased Irisin Concentrations in Patients with Crimean-Congo Hemorrhagic Fever |
|---|---|
| المؤلفون: | Deniz Bakir, Seyit Ali Büyüktuna, Derya Koç, Serpil Erşan, Halef Okan Doğan, Sevtap Bakir |
| المساهمون: | [Buyuktuna, Seyit Ali] Univ Cumhuriyet, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Dogan, Halef Okan -- Bakir, Deniz -- Ersan, Serpil -- Koc, Derya -- Bakir, Sevtap] Univ Cumhuriyet, Fac Med, Dept Biochem, Sivas, Turkey |
| بيانات النشر: | NATL INST INFECTIOUS DISEASES, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Crimean–Congo hemorrhagic fever, Adult, Male, medicine.medical_specialty, Enzyme-Linked Immunosorbent Assay, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Disease severity, Lactate dehydrogenase, Internal medicine, medicine, Humans, Platelet, In patient, Prospective Studies, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Fibronectins, 030104 developmental biology, Infectious Diseases, Endocrinology, chemistry, 030211 gastroenterology & hepatology, Female, Hemorrhagic Fever, Crimean, Hemoglobin, business, Blood Chemical Analysis, Partial thromboplastin time |
| الوصف: | WOS: 000412715600001 PubMed ID: 28250262 Crimean -Congo Hemorrhagic Fever (CCHF) is a life-threatening viral infection. The pathogenesis of the disease is not well understood. The aim of this study was to determine the change in irisin concentrations in patients with CCHF. The study included a total of 30 patients with CCHF and 30 control participants. Irisin concentrations were determined using a commercial ELISA kit. Median irisin concentrations were 9.03 (5.81-12.22) mu g/mL and 4.2 (3.39-7.62) mu g/mL, respectively, in each group. There was no correlation between irisin and disease severity. Any correlations between irisin, and lactate dehydrogenase (LDH), international normalization ratio (INR), Alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelets, activated partial thromboplastin time (aPTT), D-dimer and hemoglobin, were also investigated. There were statistically significant positive correlations between the values of irisin, and platelet (p = 0.005, r: 0.369), ALT (p = 0.049, r: 0.261), INR (p = 0.006, r: 0.359) and aPTT values (p = 0.002, r: 0.405). A negative correlation was also found between the values of irisin and LDH (p = 0.008, r: 0.348). No correlations were determined between the values of irisin, and AST, hemoglobin and D-dimer. These results suggest that irisin may have a role in CCHF. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5408c1442feca2e4ca983d0a16df08fc https://hdl.handle.net/20.500.12418/6684 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5408c1442feca2e4ca983d0a16df08fc |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |