Short Communication: HIV Type 1 Genetic Diversity among Tea Plantation Workers in Kericho, Kenya
| العنوان: | Short Communication: HIV Type 1 Genetic Diversity among Tea Plantation Workers in Kericho, Kenya |
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| المؤلفون: | Lilian Langat, Deborah L. Birx, Monique Wasunna, Nelson L. Michael, Ginamarie Foglia, Miguel A. Arroyo, Douglas Shaffer, Paul T. Scott, Francine E. McCutchan, Rukia M Kibaya, Warren B. Sateren, Merlin L. Robb, Christian T. Bautista |
| المصدر: | AIDS Research and Human Retroviruses. 25:1061-1064 |
| بيانات النشر: | Mary Ann Liebert Inc, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Rural Population, medicine.medical_specialty, Adolescent, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Logistic regression, medicine.disease_cause, Virus, Young Adult, Risk Factors, Virology, Tea plantation, Internal medicine, Ethnicity, Prevalence, Humans, Medicine, Genotyping, AIDS Vaccines, Recombination, Genetic, Molecular Epidemiology, Genetic diversity, biology, business.industry, Genetic Variation, virus diseases, biology.organism_classification, Kenya, Infectious Diseases, Mutation, Lentivirus, Cohort, HIV-1, Female, business |
| الوصف: | In preparation for HIV-1 vaccine trials in Kenya, 2801 study volunteers, from a tea plantation in Kericho, were recruited as part of a prospective vaccine cohort development study. Cryopreserved plasma was available from 401 HIV-positive volunteers, and was the source of viral RNA for genotyping by the multiregion hybridization assay (MHA). Logistic regression was performed to determine association of risk factors and HIV-1 recombinant and dual infections. At baseline, HIV-1 subtype A was the dominant circulating pure subtype (56%), followed by subtype D (10%) and C (5%). Recombinant HIV-1 strains accounted for almost one-third of all infections (29%), with 7% infected with a dual strain of the HIV-1 variants described. A higher number of HIV-1 recombinant and dual infections was observed among volunteers who were 18-24 and 25-29 years of age, affiliated with the Luo tribe, had been married two or more times, reported not being circumcised, and had STI symptoms in the past 6 months. Adjusted odds ratios (AOR) significantly associated with HIV-1 recombinant and dual infection were age difference from current spouse (5-9 years; AOR = 2.5, 95% CI = 1.2-5.3 andor = 10 years; AOR = 3.1, 95% CI = 1.5-6.4) and reported STI symptoms in the past 6 months (AOR = 4.8, 95% CI = 2.0-11.6), respectively. In conclusion, our results suggest that there is considerable heterogeneity with respect to HIV-1 subtype diversity in this population that should be considered in the planning for future vaccine trials in the region. |
| تدمد: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2009.0092 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b847c15ff058cce4b2a8ce2727ad54 https://doi.org/10.1089/aid.2009.0092 |
| رقم الانضمام: | edsair.doi.dedup.....53b847c15ff058cce4b2a8ce2727ad54 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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| DOI: | 10.1089/aid.2009.0092 |