Is it useful to detect lymphovascular invasion in lymph node-positive patients with primary operable breast cancer?
| العنوان: | Is it useful to detect lymphovascular invasion in lymph node-positive patients with primary operable breast cancer? |
|---|---|
| المؤلفون: | Isabelle de Mascarel, Gaëtan MacGrogan, Véronique Brouste, Isabelle Soubeyran, Louis Mauriac, Christine Tunon de Lara, Marc Debled, Florence Ragage, Marie Desrousseaux |
| المصدر: | Cancer. 116:3093-3101 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Oncology, Cancer Research, medicine.medical_specialty, Endothelium, Lymph node positive, Lymphovascular invasion, medicine.medical_treatment, Breast Neoplasms, Breast cancer, Internal medicine, medicine, Humans, Neoplasm Metastasis, Chemotherapy, business.industry, Cancer, Prognosis, medicine.disease, medicine.anatomical_structure, Chemotherapy, Adjuvant, Lymphatic Metastasis, Female, Endothelium, Vascular, Breast disease, Lymph, business |
| الوصف: | BACKGROUND: Lymphovascular invasion (LVI) is a widely recognized prognostic factor in lymph node-negative breast cancers. However, there are only limited and controversial data about its prognostic significance in lymph node-positive patients. METHODS: Among 931 patients operated on and monitored at the authors' institution for an invasive breast carcinoma between 1989 and 1992, all 374 lymph node-positive breast cancers entered the study (median follow-up, 126 months). RESULTS: LVI was present in 46% of tumors and was associated with age ≤40 years (P = .02), high histological grade (P = .01), and negative estrogen receptor status (P = .032), but not with tumor size, number of involved lymph nodes, or HER-2/neu status. LVI was an independent prognostic factor for distant metastases (P = .002). Furthermore, in HER-2/neu–negative/hormone receptor-positive (n = 287) tumors, the number of independent prognostic factors (LVI, age, histological grade, number of involved lymph nodes, and tumor size) was associated with a 5-years metastasis-free survival ranging from 100% if no factors (n = 25) to 89% ± 2% if 1 or 2 factors (n = 186) and 67% ± 6 if 3, 4, or 5 factors (n = 76) were present (P < .001). CONCLUSIONS: LVI is an independent prognostic factor in lymph node-positive breast cancer and merits further prospective investigations as a decision tool in the adjuvant chemotherapy setting. Cancer 2010. © 2010 American Cancer Society. |
| تدمد: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.25137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ae2c5318999e263eb8c7122724657d https://doi.org/10.1002/cncr.25137 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....53ae2c5318999e263eb8c7122724657d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
|---|---|
| DOI: | 10.1002/cncr.25137 |