Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case–control study
| العنوان: | Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case–control study |
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| المؤلفون: | Burcu Kanmaz, Christopher J. Nile, Nurcan Buduneli, Gareth Calvert, David F. Lappin, Erhan Çömlekoğlu, Pınar Meriç, Önder Gürlek |
| المساهمون: | Ege Üniversitesi |
| المصدر: | Journal of Clinical Periodontology. 46:1155-1163 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | implants, Cholinergic Agents, Osseointegration, esterases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Aggressive periodontitis, Prospective Studies, 030212 general & internal medicine, periodontitis, Cholinesterase, Dental Implants, Periodontitis, biology, business.industry, Case-control study, Gingival Crevicular Fluid, 030206 dentistry, medicine.disease, acetylcholine, SLURP-1, Aggressive Periodontitis, Case-Control Studies, Immunology, biology.protein, Periodontics, Cholinergic, Implant, business, Acetylcholine, medicine.drug |
| الوصف: | PubMed: 31444906 Aims: Periodontal diseases negatively affect implant osseointegration. Perturbations in non-neuronal cholinergic signalling mechanisms are associated with periodontitis; however, their role in generalized aggressive periodontitis (GAgP) is unknown. The aim of this prospective case–control study was to determine the relationship between non-neuronal cholinergic signalling mechanisms, secreted Ly-6/uPAR-related protein-1 (SLURP-1), interleukin-17 (IL-17) family cytokines and healing of dental implants in health and GAgP. Material and Methods: Thirteen GAgP patients and seven periodontally healthy individuals (PH) were recruited. Peri-implant crevicular fluid (PICF) was obtained at baseline and 1 month post-placement. Acetylcholine (ACh) levels and cholinesterase activity were determined biochemically. SLURP-1, IL-17A and IL-17E levels were determined by ELISA. Marginal bone loss (MBL) at 1 and 6 months post-placement was determined radiographically. Results: The concentration of ACh, cholinesterase activity and IL-17A levels was elevated in PICF of patients with GAgP compared to PH individuals at baseline and 1 month post-placement. The concentration of ACh and cholinesterase activity levels in PICF correlated with levels of IL-17A and MBL around implants 1 month post-placement in patients with GAgP. Conclusions: Non-neuronal cholinergic mechanisms may play a role in the aetiopathogenesis of GAgP and may directly or indirectly, through modulation of IL-17A, influence early implant osseointegration and potential long-term implant survival. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| وصف الملف: | application/pdf |
| تدمد: | 1600-051X 0303-6979 |
| DOI: | 10.1111/jcpe.13185 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53731c17db26e66fb36ff994283dbeff https://doi.org/10.1111/jcpe.13185 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....53731c17db26e66fb36ff994283dbeff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1600051X 03036979 |
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| DOI: | 10.1111/jcpe.13185 |