Severe hepatitis E infection during pregnancy
| العنوان: | Severe hepatitis E infection during pregnancy |
|---|---|
| المؤلفون: | P. Richardson, S. H. Hussaini, L. M. Sherratt, B. T. Cooper, J. G. O’Grady, S. J. Skidmore |
| المصدر: | Journal of Viral Hepatitis. 4:51-54 |
| بيانات النشر: | Wiley, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Pediatrics, medicine.medical_specialty, Encephalopathy, medicine.disease_cause, Hepatitis E virus, Pregnancy, Virology, medicine, Coagulopathy, Humans, Hepatitis Antibodies, Pregnancy Complications, Infectious, Hepatitis, Hepatology, biology, business.industry, Mortality rate, Liver Failure, Acute, medicine.disease, Hepatitis E, Infectious Diseases, Immunoglobulin M, Immunoglobulin G, Immunology, biology.protein, Female, business |
| الوصف: | In areas with endemic hepatitis E virus (HEV), acute liver failure secondary to hepatitis E infection is common in pregnancy and associated with a mortality rate of up to 20%. However, there is little information on the clinical course of severe hepatitis E infection during pregnancy in non-endemic areas such as the UK. Here we describe two cases of severe hepatitis E in pregnancy in patients returning from the Indian subcontinent. These cases were diagnosed by the detection of IgM anti-HEV antibody using an enzyme immunoassay with recombinant hepatitis E viral antigens. The first case describes acute hepatic failure, with coagulopathy and encephalopathy, warranting intensive therapy and elective ventilation. In the other case, the patient had severe hepatitis with coagulopathy. Both cases spontaneously resolved with no foetal loss. These cases highlight the need for suspicion of HEV infection in patients returning from endemic areas and presenting with acute non-A non-B hepatitis, especially when pregnant. Furthermore, the intensive treatment of acute liver failure caused by HEV may reduce the high mortality reported in Asia. |
| تدمد: | 1365-2893 1352-0504 |
| DOI: | 10.1046/j.1365-2893.1997.00123.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535657b835f6333eddfb6f1a4c718d37 https://doi.org/10.1046/j.1365-2893.1997.00123.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....535657b835f6333eddfb6f1a4c718d37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652893 13520504 |
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| DOI: | 10.1046/j.1365-2893.1997.00123.x |