Impact of corticosteroids on late growth of radiofrequency lesions in infant pigs: histopathological and electroanatomical findings
| العنوان: | Impact of corticosteroids on late growth of radiofrequency lesions in infant pigs: histopathological and electroanatomical findings |
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| المؤلفون: | Angelo Amato Vincenzo de Paola, Luis Felipe Neves dos Santos, Guilherme Fenelon, Sérgio de Araújo, Elerson Arfelli, Marcello Franco, Thais Nascimento, Mieko Okada |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP) |
| المصدر: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Electroanatomical mapping, Pathology, medicine.medical_specialty, Hydrocortisone, Swine, Heart Ventricles, Scars, Arrhythmias, Lesion, Cicatrix, Adrenal Cortex Hormones, Fibrosis, Prednisone, Normal muscle, Physiology (medical), medicine, Animals, Corticosteroids, Heart Atria, Cell Proliferation, business.industry, Radiofrequency ablation, medicine.disease, medicine.anatomical_structure, Ventricle, Models, Animal, Catheter Ablation, Right atrium, Collagen, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Aims Corticosteroids attenuate late growth of radiofrequency (RF) lesions in the thigh muscle of infant rats. We sought to assess the impact of these drugs on the late growth of RF lesions in immature swine myocardium and to determine the electroanatomical mapping (EAM) characteristics of these lesions.Methods and results Radiofrequency (60 degrees C; 60 s) lesions were created in the right atrium (n = 2) and ventricle (n = 2) of 14 piglets (age 65 days; weight 5 kg) and 3 adults. Piglets were divided into: controls (n 7) and treated (n 7), receiving hydrocortisone (10 mg/kg iv after RF) and prednisone (1 mg/kg/day) for 29 days. After 8 months, animals were sacrificed for histological analysis. in four piglets, endocardial and epicardial voltage EAM were performed.In infant groups, the dimensions of atrial (11 +/- 5 vs. 13 +/- 7 mm) and ventricular (12 +/- 3 vs. 11 +/- 3 mm) lesions were similar. in adults, atrial (6 +/- 1 mm) and ventricular (6 +/- 1 mm) lesions were smaller. in controls, ventricular lesions depicted dense fibrosis and multiple strands of fibrous tissue extending from the lesion into normal muscle. Treated piglets revealed scars exhibiting less dense fibrosis with predominance of fibroadipose tissue and less collagen proliferation. Large atrial and ventricular low-voltage areas corresponding to the macroscopic lesions were identified in all animals.Conclusion Radiofrequency lesions in infant pigs reveal late growth and invasion of normal muscle by intense collagen proliferation. Corticosteroids do not prevent late enlargement of the lesions but modulate the fibrotic proliferation. the expressive growth of the lesion may generate low-voltage areas detectable by EAM. Universidade Federal de São Paulo, Discipline Cardiol, Paulista Sch Med, BR-04039030 São Paulo, Brazil Universidade Federal de São Paulo, Dept Pathol, Paulista Sch Med, BR-04039030 São Paulo, Brazil Universidade Federal de São Paulo, Discipline Cardiol, Paulista Sch Med, BR-04039030 São Paulo, Brazil Universidade Federal de São Paulo, Dept Pathol, Paulista Sch Med, BR-04039030 São Paulo, Brazil Web of Science |
| تدمد: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/euq391 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f30346128e6251eb788f58760c94d2 https://doi.org/10.1093/europace/euq391 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....52f30346128e6251eb788f58760c94d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322092 10995129 |
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| DOI: | 10.1093/europace/euq391 |