A case-control study to evaluate the impact of the breast screening programme on mortality in England
| العنوان: | A case-control study to evaluate the impact of the breast screening programme on mortality in England |
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| المؤلفون: | Roberta Maroni, Dharmishta Parmar, Stephen W. Duffy, Jack Cuzick, Amanda Dibden, Nathalie J. Massat, Peter Sasieni |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Breast cancer mortality, MEDLINE, Breast Neoplasms, Logistic regression, Article, State Medicine, Cancer screening, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, Breast screening, Humans, 030212 general & internal medicine, Date of birth, Mortality, Early Detection of Cancer, Aged, Aged, 80 and over, business.industry, Obstetrics, Case-control study, Middle Aged, medicine.disease, Logistic Models, Oncology, England, 030220 oncology & carcinogenesis, Case-Control Studies, Female, Risk of death, business |
| الوصف: | BackgroundOver the past 30 years since the implementation of the National Health Service Breast Screening Programme, improvements in diagnostic techniques and treatments have led to the need for an up-to-date evaluation of its benefit on risk of death from breast cancer. An initial pilot case-control study in London indicated that attending mammography screening led to a mortality reduction of 39%.MethodsBased on the same study protocol, an England-wide study was set up. Women aged 47–89 years who died of primary breast cancer in 2010 or 2011 were selected as cases (8288 cases). When possible, two controls were selected per case (15,202 controls) and were matched by date of birth and screening area.ResultsConditional logistic regressions showed a 38% reduction in breast cancer mortality after correcting for self-selection bias (OR 0.62, 95% CI 0.56–0.69) for women being screened at least once. Secondary analyses by age group, and time between last screen and breast cancer diagnosis were also performed.ConclusionsAccording to this England-wide case-control study, mammography screening still plays an important role in lowering the risk of dying from breast cancer. Women aged 65 or over see a stronger and longer lasting benefit of screening compared to younger women. |
| اللغة: | English |
| تدمد: | 1532-1827 0007-0920 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a2e03c229e23b60d32983c15921756 http://europepmc.org/articles/PMC7884709 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....52a2e03c229e23b60d32983c15921756 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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