Copper-Catalyzed Coupling of Thioamides and Donor/Acceptor-Substituted Carbenoids: Synthesis of Enamino Esters and Enaminones
| العنوان: | Copper-Catalyzed Coupling of Thioamides and Donor/Acceptor-Substituted Carbenoids: Synthesis of Enamino Esters and Enaminones |
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| المؤلفون: | Arpan Pal, Syed R. Hussaini |
| المصدر: | ACS Omega ACS Omega, Vol 4, Iss 1, Pp 269-280 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 010405 organic chemistry, General Chemical Engineering, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Copper, Coupling reaction, Article, 3. Good health, 0104 chemical sciences, Catalysis, lcsh:Chemistry, chemistry.chemical_compound, chemistry, lcsh:QD1-999, Bromide, Copper catalyzed, Thiocarbamates, Donor acceptor, Catalytic method |
| الوصف: | The coupling of thioamides and donor/acceptor-substituted diazocarbonyl compounds is reported for the first time. The present report provides a mild, catalytic method that couples thioamides and donor/acceptor-substituted diazocarbonyl compounds to form enamino esters and enaminones. Unlike traditional methods for the synthesis of enamino esters and enaminones from thioamides, both N-alkyl thioamides and thiocarbamates are suitable substrates in this coupling reaction. Copper(I) bromide catalyzes the reaction and provides enamino esters and enaminones chemo- and diastereoselectively in less time than Rh2(OAc)4 or Ru(PPh3)3Cl2 catalysts. |
| تدمد: | 2470-1343 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5284604354f794677250c1e3b18179c6 https://pubmed.ncbi.nlm.nih.gov/31459329 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5284604354f794677250c1e3b18179c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24701343 |
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