Cure of Mice Infected with Trypanosoma rhodesiense by cis -Diamminedichloroplatinum (ii) and Disulfiram Rescue
| العنوان: | Cure of Mice Infected with Trypanosoma rhodesiense by cis -Diamminedichloroplatinum (ii) and Disulfiram Rescue |
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| المؤلفون: | Leonard A. Zwelling, James E. Sanders, Michael S. Wysor, Marie M. Grenan |
| المصدر: | Science. 217:454-456 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1982. |
| سنة النشر: | 1982 |
| مصطلحات موضوعية: | Male, Trypanosoma, endocrine system diseases, medicine.medical_treatment, Sodium Chloride, Pharmacology, Kidney, Body weight, Mice, Necrosis, Disulfiram, medicine, Animals, Saline, Renal necrosis, Mice, Inbred ICR, Cis diamminedichloroplatinum ii, Multidisciplinary, Renal damage, business.industry, Rats, Trypanosomiasis, African, Cisplatin, Trypanosoma rhodesiense, business, medicine.drug |
| الوصف: | Mice infected with Trypanosoma rhodesiense were treatment concurrently with cis-diamminedichloroplatinum (II) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice. The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice. |
| تدمد: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.7201165 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e0a0d8171d2c4cc2f8d95eb7d5a7ae https://doi.org/10.1126/science.7201165 |
| رقم الانضمام: | edsair.doi.dedup.....51e0a0d8171d2c4cc2f8d95eb7d5a7ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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| DOI: | 10.1126/science.7201165 |