Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
| العنوان: | Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice |
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| المؤلفون: | Brian C. Gliniak, E Maraskovsky, Philip J. Morrissey, D E Williams, J J Peschon, F J Ramsdell, J. Meyer, L S Park, C B Ware, Kenneth H. Grabstein, B L Davison, Steven F. Ziegler |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Male, CD8 Antigens, Sialoglycoproteins, Immunology, Interleukin 1 receptor, type II, Biology, Mice, Antigens, CD, Interleukin-4 receptor, Animals, Immunology and Allergy, Lymphocytes, Interleukin 3, Leukosialin, Receptors, Interleukin-7, Interleukin-7, Receptors, Interleukin-2, Articles, Receptors, Interleukin, Molecular biology, Mice, Inbred C57BL, Thymocyte, Interleukin 10, Interleukin-21 receptor, CD4 Antigens, Interleukin-6 receptor, Female, Interleukin 1 receptor, type I |
| الوصف: | Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL-7R. Mutant mice display a profound reduction in thymic and peripheral lymphoid cellularity. Analyses of lymphoid progenitor populations in IL-7R-deficient mice define precisely those developmental stages affected by the mutation and reveal a critical role for IL-7R during early lymphoid development. Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7. |
| تدمد: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.180.5.1955 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a76552f7b383fc57b6589c36cf1b86 https://doi.org/10.1084/jem.180.5.1955 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51a76552f7b383fc57b6589c36cf1b86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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| DOI: | 10.1084/jem.180.5.1955 |