Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery
| العنوان: | Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery |
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| المؤلفون: | Marcelo Febo, Asahi Tomitaka, Anthony J. McGoron, Yasushi Takemura, Arash Ahmadivand, Nezih Pala, Hamed Arami, Madhavan Nair |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Materials science, lcsh:Medicine, Nanotechnology, 02 engineering and technology, Multifunctional Nanoparticles, 010402 general chemistry, 01 natural sciences, Ferric Compounds, Multimodal Imaging, Article, Magnetics, Magnetic particle imaging, Drug Delivery Systems, medicine, Nanobiotechnology, Animals, Humans, Surface plasmon resonance, Precision Medicine, lcsh:Science, Magnetite Nanoparticles, Plasmon, Multidisciplinary, Nanoscale materials, medicine.diagnostic_test, lcsh:R, technology, industry, and agriculture, Magnetic resonance imaging, Phototherapy, 021001 nanoscience & nanotechnology, Magnetic Resonance Imaging, 0104 chemical sciences, Drug Liberation, Nanomedicine, Heat generation, Drug delivery, lcsh:Q, Gold, 0210 nano-technology, Electromagnetic Phenomena |
| الوصف: | Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519bad405d700a3bd5a2e31b49feec79 https://pubmed.ncbi.nlm.nih.gov/32572041 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....519bad405d700a3bd5a2e31b49feec79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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