Lower Efficacy in the Utilization of Dietary ALA as Compared to Preformed EPA + DHA on Long Chain n-3 PUFA Levels in Rats
| العنوان: | Lower Efficacy in the Utilization of Dietary ALA as Compared to Preformed EPA + DHA on Long Chain n-3 PUFA Levels in Rats |
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| المؤلفون: | Ramaprasad Ravichandra Talahalli, Belur R. Lokesh, Baskaran Vallikannan, Kari Sambaiah |
| المصدر: | Lipids. 45:799-808 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, food.ingredient, Docosahexaenoic Acids, Linolenic acid, Biochemistry, chemistry.chemical_compound, Blood serum, food, Linseed oil, Fatty Acids, Omega-3, Animals, Food science, Rats, Wistar, chemistry.chemical_classification, alpha-Linolenic acid, Organic Chemistry, alpha-Linolenic Acid, food and beverages, Cell Biology, Fish oil, Eicosapentaenoic acid, Rats, Eicosapentaenoic Acid, chemistry, Docosahexaenoic acid, lipids (amino acids, peptides, and proteins), Polyunsaturated fatty acid |
| الوصف: | We made a comparative analysis of the uptake, tissue deposition and conversion of dietary alpha-linolenic acid (ALA) to its long chain metabolites eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with preformed EPA + DHA. Diets containing linseed oil [with ALA at approximately 2.5 (4 g/kg diet), 5 (8 g/kg diet), 10 (16 g/kg diet), 25% (40 g/kg diet)] or fish oil [with EPA + DHA at approximately 1 (1.65 g/kg diet), 2.5 (4.12 g/kg diet), 5% (8.25 g/kg diet)] or groundnut oil without n-3 polyunsaturated fatty acids (n-3 PUFA) were fed to rats for 60 days. ALA and EPA + DHA in serum, liver, heart and brain increased with increments in the dietary ALA level. When preformed EPA + DHA were fed, the tissue EPA + DHA increased significantly compared to those given ALA. Normalized values from dietary n-3 PUFA to tissue EPA + DHA indicated that 100 mg of dietary ALA lead to accumulation of EPA + DHA at 2.04, 0.70, 1.91 and 1.64% of total fatty acids respectively in liver, heart, brain and serum. Similarly 100 mg of preformed dietary EPA + DHA resulted in 25.4, 23.8, 15.9 and 14.9% of total fatty acids in liver, heart, brain and serum respectively. To maintain a given level of EPA + DHA, the dietary ALA required is 12.5, 33.5, 8.3 and 9.1 times higher than the dietary EPA + DHA for liver, heart, brain and serum respectively. Hence the efficacy of precursor ALA is lower compared to preformed EPA + DHA in elevating serum and tissue long chain n-3 PUFA levels. |
| تدمد: | 1558-9307 0024-4201 |
| DOI: | 10.1007/s11745-010-3464-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5188913a9ab82a646f2f19bf4d161ef2 https://doi.org/10.1007/s11745-010-3464-6 |
| رقم الانضمام: | edsair.doi.dedup.....5188913a9ab82a646f2f19bf4d161ef2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15589307 00244201 |
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| DOI: | 10.1007/s11745-010-3464-6 |