Lipoteichoic acid reduces antioxidant enzymes in H9c2 cells
| العنوان: | Lipoteichoic acid reduces antioxidant enzymes in H9c2 cells |
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| المؤلفون: | Gloria Gutiérrez-Venegas, Berenice Fernández-Rojas, José Pedraza-Chaverri, Gustavo Ignacio Vázquez-Cervantes |
| المصدر: | Toxicology Reports Toxicology Reports, Vol 7, Iss, Pp 101-108 (2020) |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Antioxidant, Health, Toxicology and Mutagenesis, medicine.medical_treatment, ERK, extracellular signal-regulated kinases, 010501 environmental sciences, Toxicology, medicine.disease_cause, 01 natural sciences, GPx-1, glutathione peroxidase-1, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, chemistry.chemical_compound, 0302 clinical medicine, Carboxy-H2DCFDA, 6-carboxy-2´,7´ dichlorodihydrofluorescein diacetate, LTA, lipoteichoic acid, GSH, glutathione, ROS production, NOS, nitric oxide synthase, chemistry.chemical_classification, biology, Chemistry, OH•, hydroxyl radical, Glutathione peroxidase, Regular Article, respiratory system, IE, infective endocarditis, Catalase, H2O2, hydrogen peroxide, O2•¯, superoxide radical, Antioxidant enzymes, lipids (amino acids, peptides, and proteins), Lipoteichoic acid, FDA, fluorescein diacetate, JNK, c-jun N-terminal kinases, SOD-1, superoxide dismutase-1, AKT, protein kinase B, ONOO¯, peroxynitrite anion, Microbiology, RNS, reactive nitrogen species, Superoxide dismutase, 03 medical and health sciences, ROS, reactive oxygen species, lcsh:RA1190-1270, medicine, Nrf2, nuclear factor (erythroid-derived 2)-like 2, lcsh:Toxicology. Poisons, ComputingMethodologies_COMPUTERGRAPHICS, 0105 earth and related environmental sciences, NO, nitric oxide, Reactive oxygen species, Glutathione, Oxidative stress, biology.protein, CAT, catalase, Infective endocarditis, DHE, dihydroethidium, MAPK, mitogen-activated protein kinase, 030217 neurology & neurosurgery |
| الوصف: | Graphical abstract Highlights • Lipoteichoic acid (LTA) reduced the levels of the antioxidant enzymes in H9c2 cells. • LTA from Streptococcus sanguinis induced ROS production in H9c2 cells. • Low antioxidant enzymes levels and ROS production could be related to infective endocarditis (IE). • Antioxidants could protect against oxidative stress induced by LTA in IE. Infective endocarditis (IE) is an illness where the heart is invaded by bacteria, like Streptococcal and Staphylococcal species that contain lipoteichoic acid (LTA) related to an essential role in this disease. This study is the first in evaluating antioxidant enzyme levels in embryonic cardiomyocyte cell line (H9c2) induced by LTA from Streptococcus sanguinis. LTA increased reactive oxygen species (ROS) and reduced the levels of the antioxidant enzymes glutathione peroxidase, superoxide dismutase (SOD)-1 and catalase (CAT) but did not affect glutathione content. At the highest LTA concentration (15 μg/ml), SOD-1 and CAT levels did not change, and this effect was related to the induction of mRNA levels of Nrf2 induced by LTA. These results suggest that low antioxidant enzyme levels and ROS production could be related to IE. |
| تدمد: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2019.12.007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51499fcc0fda5a05a7ea44fe2d3e0ae6 https://doi.org/10.1016/j.toxrep.2019.12.007 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51499fcc0fda5a05a7ea44fe2d3e0ae6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22147500 |
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| DOI: | 10.1016/j.toxrep.2019.12.007 |