Signal transduction pathway mutations in gastrointestinal (GI) cancers : a systematic review and meta-analysis
| العنوان: | Signal transduction pathway mutations in gastrointestinal (GI) cancers : a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Farhad Zamani, Mohammad Hadi Karbalaie Niya, Fahimeh Safarnezhad Tameshkel, Maryam Esghaei, Maziar Moradi-Lakeh, Alireza Mousavi-Jarrahi, G. Hossein Ashrafi, Mahshid Panahi, Yousef Moradi, Nima Motamed, Alireza Tabibzadeh, Saber Soltani, Hossein Ajdarkosh, Seyed Abbas Motevalian |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-24 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, MAPK/ERK pathway, medicine.medical_specialty, Class I Phosphatidylinositol 3-Kinases, MAP Kinase Signaling System, Molecular biology, Colorectal cancer, Adenomatous Polyposis Coli Protein, DNA Mutational Analysis, lcsh:Medicine, medicine.disease_cause, Article, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, Internal medicine, Prevalence, Genetics, Humans, Medicine, cancer, lcsh:Science, Wnt Signaling Pathway, PI3K/AKT/mTOR pathway, Gastrointestinal Neoplasms, Multidisciplinary, business.industry, lcsh:R, Wnt signaling pathway, Cancer, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, lcsh:Q, KRAS, business, Liver cancer, biological, Signal Transduction |
| الوصف: | The present study was conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers in a systematic review and meta-analysis study. The study was performed based on the PRISMA criteria. Random models by confidence interval (CI: 95%) were used to calculate the pooled estimate of prevalence via Metaprop command. The pooled prevalence indices of signal transduction pathway mutations in gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer were 5% (95% CI: 3–8%), 12% (95% CI: 8–18%), 17% (95% CI: 14–20%), and 20% (95% CI: 5–41%), respectively. Also, the mutation rates for Wnt pathway and MAPK pathway were calculated to be 23% (95% CI, 14–33%) and 20% (95% CI, 17–24%), respectively. Moreover, the most popular genes were APC (in Wnt pathway), KRAS (in MAPK pathway) and PIK3CA (in PI3K pathway) in the colorectal cancer, pancreatic cancer, and gastric cancer while they were beta-catenin and CTNNB1 in liver cancer. The most altered pathway was Wnt pathway followed by the MAPK pathway. In addition, pancreatic cancer was found to be higher under the pressure of mutation compared with others based on pooled prevalence analysis. Finally, APC mutations in colorectal cancer, KRAS in gastric cancer, and pancreatic cancer were mostly associated gene alterations. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5136b31ecfa0f540549a55cb61746c90 https://eprints.kingston.ac.uk/id/eprint/47359/7/Ashrafi-G-H-47359-VoR.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5136b31ecfa0f540549a55cb61746c90 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |