Chemical Deprenylation of N 6 ‐Isopentenyladenosine (i 6 A) RNA
| العنوان: | Chemical Deprenylation of N 6 ‐Isopentenyladenosine (i 6 A) RNA |
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| المؤلفون: | Tian-Qi Zhang, Xiao-Hui Yang, Hou-Ping Cheng, Liang Cheng, Cuimei Liu, Li Liu, Li-Jun Xie, Zhi-Yan Li, Chuan Chen, Ling Lan, Du-Qiang Luo, Jinfang Chu |
| المصدر: | Angewandte Chemie International Edition. 59:10645-10650 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | biology, 010405 organic chemistry, Oligonucleotide, Chemistry, fungi, food and beverages, RNA, Translation (biology), General Medicine, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Prenylation, Biochemistry, Cytokinin, Arabidopsis thaliana, Isopentenyladenosine, Function (biology) |
| الوصف: | N6 -isopentenyladenosine (i6 A) is an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. The installation and removal of this modification is mediated by prenyltransferases and cytokinin oxidases, and a chemical approach to selective deprenylation of i6 A has not been developed. We show that a selected group of oxoammonium cations function as artificial deprenylases to promote highly selective deprenylation of i6 A in nucleosides, oligonucleotides, and live cells. Importantly, other epigenetic modifications, amino acid residues, and natural products were not affected. Moreover, a significant phenotype difference in the Arabidopsis thaliana shoot and root development was observed with incubation of the cation. These results establish these small organic molecules as direct chemical regulators/artificial deprenylases of i6 A. |
| تدمد: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.202003360 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511216591f250f662553d7e315f914a8 https://doi.org/10.1002/anie.202003360 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....511216591f250f662553d7e315f914a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213773 14337851 |
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| DOI: | 10.1002/anie.202003360 |