Impact of specimen adequacy on the assessment of renal allograft biopsy specimens
| العنوان: | Impact of specimen adequacy on the assessment of renal allograft biopsy specimens |
|---|---|
| المؤلفون: | L. Geldenhuys, Sanem Guler, Abdurrahim Imamoglu, Michele Molinari, Sertac Cimen |
| المصدر: | Brazilian Journal of Medical and Biological Research, Volume: 49, Issue: 4, Article number: e5301, Published: 26 APR 2016 Brazilian Journal of Medical and Biological Research, Vol 49, Iss 4 (2016) Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research v.49 n.4 2016 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Graft Rejection, Male, Medicine (General), Physiology, Renal allograft, Biopsy, 030230 surgery, Kidney, Biochemistry, 0302 clinical medicine, General Pharmacology, Toxicology and Pharmaceutics, Biology (General), lcsh:QH301-705.5, Observer Variation, lcsh:R5-920, medicine.diagnostic_test, General Neuroscience, General Medicine, Allografts, Exact test, Specimen Quality, 030220 oncology & carcinogenesis, Female, Radiology, lcsh:Medicine (General), medicine.medical_specialty, QH301-705.5, Immunology, Biophysics, Ocean Engineering, Specimen adequacy, 03 medical and health sciences, R5-920, medicine, Humans, Clinical Investigation, Retrospective Studies, business.industry, Reproducibility of Results, Retrospective cohort study, Small sample, Cell Biology, Kidney Transplantation, Surgery, Transplantation, lcsh:Biology (General), business, Banff criteria, Kappa |
| الوصف: | The Banff classification was introduced to achieve uniformity in the assessment of renal allograft biopsies. The primary aim of this study was to evaluate the impact of specimen adequacy on the Banff classification. All renal allograft biopsies obtained between July 2010 and June 2012 for suspicion of acute rejection were included. Pre-biopsy clinical data on suspected diagnosis and time from renal transplantation were provided to a nephropathologist who was blinded to the original pathological report. Second pathological readings were compared with the original to assess agreement stratified by specimen adequacy. Cohen's kappa test and Fisher's exact test were used for statistical analyses. Forty-nine specimens were reviewed. Among these specimens, 81.6% were classified as adequate, 6.12% as minimal, and 12.24% as unsatisfactory. The agreement analysis among the first and second readings revealed a kappa value of 0.97. Full agreement between readings was found in 75% of the adequate specimens, 66.7 and 50% for minimal and unsatisfactory specimens, respectively. There was no agreement between readings in 5% of the adequate specimens and 16.7% of the unsatisfactory specimens. For the entire sample full agreement was found in 71.4%, partial agreement in 20.4% and no agreement in 8.2% of the specimens. Statistical analysis using Fisher's exact test yielded a P value above 0.25 showing that - probably due to small sample size - the results were not statistically significant. Specimen adequacy may be a determinant of a diagnostic agreement in renal allograft specimen assessment. While additional studies including larger case numbers are required to further delineate the impact of specimen adequacy on the reliability of histopathological assessments, specimen quality must be considered during clinical decision making while dealing with biopsy reports based on minimal or unsatisfactory specimens. |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dceb97c4ac4b5c8dd873406ec8793d http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400710&lng=en&tlng=en |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....50dceb97c4ac4b5c8dd873406ec8793d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |