Severe Acute Respiratory Syndrome Coronavirus 2 Serosurveillance in a Patient Population Reveals Differences in Virus Exposure and Antibody-Mediated Immunity According to Host Demography and Healthcare Setting
| العنوان: | Severe Acute Respiratory Syndrome Coronavirus 2 Serosurveillance in a Patient Population Reveals Differences in Virus Exposure and Antibody-Mediated Immunity According to Host Demography and Healthcare Setting |
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| المؤلفون: | Yasmin A Parr, Alice Broos, Annachiara Rosa, Agnieszka M. Szemiel, Norah Palmateer, Chloe Roustan, Antonia Ho, Mafalda Viana, Peter Cherepanov, Pablo R. Murcia, Ellen C Hughes, Rory Gunson, Sema Nickbakhsh, Andrew McAuley, Julien A R Amat, Nicola S Logan, Brian J. Willett, E. Dickson, Imogen Herbert, Joanne Haney, Ursula Arthur |
| المصدر: | The Journal of Infectious Diseases |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Virus exposure, Adolescent, Cross-sectional study, Seroprevalence, Enzyme-Linked Immunosorbent Assay, medicine.disease_cause, Antibodies, Viral, Virus, Modelling, Herd immunity, Serology, Cell Line, Young Adult, Risk Factors, Seroepidemiologic Studies, Epidemiology, Pandemic, medicine, Major Article, Humans, Immunology and Allergy, Pandemics, Coronavirus, Aged, Demography, business.industry, SARS-CoV-2, Immunity, COVID-19, Virus Neutralisation, Middle Aged, Antibodies, Neutralizing, Cross-Sectional Studies, AcademicSubjects/MED00290, Infectious Diseases, Scotland, Immunology, Female, business, Delivery of Health Care |
| الوصف: | Identifying drivers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and quantifying population immunity is crucial to prepare for future epidemics. We performed a serial cross-sectional serosurvey throughout the first pandemic wave among patients from the largest health board in Scotland. Screening of 7480 patient serum samples showed a weekly seroprevalence ranging from 0.10% to 8.23% in primary and 0.21% to 17.44% in secondary care, respectively. Neutralization assays showed that highly neutralizing antibodies developed in about half of individuals who tested positive with enzyme-linked immunosorbent assay, mainly among secondary care patients. We estimated the individual probability of SARS-CoV-2 exposure and quantified associated risk factors. We show that secondary care patients, male patients, and 45–64-year-olds exhibit a higher probability of being seropositive. The identification of risk factors and the differences in virus neutralization activity between patient populations provided insights into the patterns of virus exposure during the first pandemic wave and shed light on what to expect in future waves. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiaa788 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5070a59a21d4673ed4dd172bba5a0f04 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5070a59a21d4673ed4dd172bba5a0f04 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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| DOI: | 10.1093/infdis/jiaa788 |