Calcium handling in vasoconstriction to stimulation of alpha1- and alpha2-adrenoceptors
| العنوان: | Calcium handling in vasoconstriction to stimulation of alpha1- and alpha2-adrenoceptors |
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| المؤلفون: | Pieter B.M.W.M. Timmermans, Martin J.M.C. Thoolen, Anddrew T. Chiu |
| المصدر: | Canadian Journal of Physiology and Pharmacology. 65:1649-1657 |
| بيانات النشر: | Canadian Science Publishing, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Pharmacology, medicine.medical_specialty, Adrenergic receptor, Physiology, Chemistry, Stimulation, General Medicine, Receptors, Adrenergic, alpha, Calcium Channel Blockers, Endocrinology, Nifedipine, Vasoconstriction, Postsynaptic potential, Physiology (medical), Internal medicine, medicine, Extracellular, Animals, Verapamil, Calcium, Channel blocker, medicine.symptom, Adrenergic alpha-Agonists, medicine.drug |
| الوصف: | Vasoconstriction to stimulation of postsynaptic alpha1- and alpha2-adrenoceptors involves different mechanisms of Ca2+ mobilization. Alpha2-adrenoceptor-mediated vasoconstriction in vivo as well as in vitro is invariably and effectively antagonized by Ca2+ channel blockers, such as nifedipine or verapamil, and is therefore primarily carried by influx of extracellular Ca2+. On the other hand, alpha1-adrenoceptor stimulation has been linked to both influx of extracellular Ca2+ and release of Ca2+ from intracellular stores. The sensitivity of alpha1-adrenoceptor-mediated vasoconstriction to blockade by Ca2+ channel antagonists depends on how much both mechanisms of Ca2+ mobilization contribute to the contraction process, and varies between vascular tissues and alpha1 -adrenoceptor agonists. The experimental evidence for the differential utilization of Ca2+ in vasoconstriction to alpha1- and alpha2-adrenoceptor stimulation is reviewed. |
| تدمد: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y87-259 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5b969652dad14ea1034c87c9fb1189 https://doi.org/10.1139/y87-259 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4f5b969652dad14ea1034c87c9fb1189 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12057541 00084212 |
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| DOI: | 10.1139/y87-259 |