التفاصيل البيبلوغرافية
العنوان:
Association study of the serotoninergic system in migraine in the Spanish population
المؤلفون:
Alfons Macaya , E. Cuenca-Leon , Manuel Roig , María-Jesús Sobrido , Roser Corominas , M. Ribasés , Bru Cormand , J. López-González , Rogelio Leira , Bernat Narberhaus , Patricia Blanco-Arias
المصدر:
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics . (1)
سنة النشر:
2009
مصطلحات موضوعية:
Serotonin , Migraine Disorders , Population , Single-nucleotide polymorphism , Biology , Polymorphism, Single Nucleotide , Cellular and Molecular Neuroscience , Genetic variation , Receptor, Serotonin, 5-HT2B , medicine , Genetic predisposition , Humans , Allele , education , Monoamine Oxidase , Genetics (clinical) , Genetics , education.field_of_study , Haplotype , Epistasis, Genetic , medicine.disease , Migraine with aura , Psychiatry and Mental health , Migraine , Spain , Case-Control Studies , Dopa Decarboxylase , medicine.symptom , Genome-Wide Association Study
الوصف:
In order to evaluate the contribution of 19 serotonin-related genes to the susceptibility to migraine in a Spanish population we performed a case - control association study of 122 single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters, in 528 migraine patients - 308 with migraine without aura (MO) and 220 with migraine with aura (MA) - and 528 sex-matched migraine-free controls. The single-marker analysis identified nominal associations with the migraine phenotype or with the MO or MA subtypes. The multiple-marker analysis revealed risk haplotypes in three genes that remained significantly associated with migraine after correction by permutations. Two-marker risk haplotypes were identified in theHTR2B(rs16827801T-rs10194776G) andMAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2044859T-rs11761683G). The present study supports the involvement of HTR2B and MAOA genes in the genetic predisposition to MO, while DDC might confer susceptibility to MA. These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA. © 2009 Wiley-Liss, Inc.
تدمد:
1552-485X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebd13adc4710a67d42836dbdb1becf8 https://pubmed.ncbi.nlm.nih.gov/19455600
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....4ebd13adc4710a67d42836dbdb1becf8
قاعدة البيانات:
OpenAIRE