Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
| العنوان: | Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 |
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| المؤلفون: | Sewon Kang, Nashay N. Clemetson, Ang Li, Luis A. Garza, Jace W. Jones, Angela Park, Dongwon Kim, Lloyd S. Miller, Maureen A. Kane, Wooyang Son, S. Kim, Weiliang Huang, Gaofeng Wang, Ruosi Chen, Ginette A. Okoye, Victoria Yu, Mary Sheu, Gabriel Ghiaur, Zixiao Wang, Eugene Oh, Anna Chien, Vicky P. Prizmic, Zhiqi Hu, Benjamin R. Evans, Jianshi Yu, Noori Kim, Amanda M. Nelson, Eric M. Wier, Nathan K. Archer, Nasif Islam |
| المصدر: | Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) Nature Communications |
| بيانات النشر: | Nature Portfolio, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Retinoic acid, General Physics and Astronomy, 02 engineering and technology, Benzoates, Neogenesis, Non-coding RNAs, chemistry.chemical_compound, Mice, RNA interference, Stilbenes, RNA, Small Interfering, lcsh:Science, Mice, Knockout, Toll-like receptor, Multidisciplinary, biology, integumentary system, Middle Aged, 021001 nanoscience & nanotechnology, 3. Good health, Cell biology, medicine.anatomical_structure, Female, RNA Interference, Stem cell, 0210 nano-technology, Hair Follicle, Science, Tretinoin, General Biochemistry, Genetics and Molecular Biology, Article, Skin models, 03 medical and health sciences, medicine, Animals, Humans, Regeneration, RNA, Double-Stranded, Wound Healing, Interleukin-6, General Chemistry, biology.organism_classification, Hair follicle, Toll-Like Receptor 3, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Gene Expression Regulation, TLR3, lcsh:Q, Wound healing, Hair |
| الوصف: | How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity. During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human keratinocyte cells. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e552ed3ba8c7d754c0d42d4bff3214b https://doaj.org/article/564f599801064b9c89f41e9691fc9196 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4e552ed3ba8c7d754c0d42d4bff3214b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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