Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd
| العنوان: | Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd |
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| المؤلفون: | Salomé Gonçalves-Monteiro, Edgar Pinto, Helder Mota-Filipe, Agostinho Almeida, Sára Kalivodová, Clara B. Martins, Ana L. M. Batista de Carvalho, Isabel M.P.L.V.O. Ferreira, Maria Paula M. Marques, Martin Vojtek, Carmen Diniz |
| المساهمون: | Repositório Científico do Instituto Politécnico do Porto |
| المصدر: | Pharmaceuticals Volume 14 Issue 2 Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Pharmaceuticals, Vol 14, Iss 173, p 173 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Biodistribution, polyamines, Pharmaceutical Science, Adipose tissue, Spermine, chemistry.chemical_element, lcsh:Medicine, lcsh:RS1-441, cisplatin, metal complexes, Pharmacology, Article, lcsh:Pharmacy and materia medica, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, In vivo, Metal complexes, Drug Discovery, medicine, Polyamines, ICP-MS, cancer, Cancer, Cisplatin, Tissue, Chemistry, Pd(II)-based drugs, lcsh:R, tissue, In vitro, in vivo, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Cisplatin ICP-MS, medicine.drug, Palladium |
| الوصف: | Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinetic profiles of palladium/platinum in serum, serum ultrafiltrate and tissues (kidney, liver, brain, heart, lungs, ovaries, adipose tissue and mammary glands) were studied in healthy female Balb/c mice after a single intraperitoneal bolus injection of Pd2Spm (3 mg/kg bw) or cisplatin (3.5 mg/kg bw) between 0.5 and 48 h post-injection. Palladium in serum exhibited biphasic kinetics with a terminal half-life of 20.7 h, while the free palladium in serum ultrafiltrate showed a higher terminal half-life than platinum (35.5 versus 31.5 h). Palladium was distributed throughout most of the tissues except for the brain, with the highest values in the kidney, followed by the liver, lungs, ovaries, adipose tissue and mammary glands. The in vitro cellular accumulation was also evaluated in breast cancer cells, evidencing a passive diffusion as a mechanism of Pd2Spm’s cellular entry. This study reports, for the first time, the favorable pharmacokinetics and biodistribution of Pd2Spm, which may become a promising pharmacological agent for cancer treatment. |
| وصف الملف: | application/pdf; text/plain; charset=utf-8 |
| تدمد: | 1424-8247 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1ceb2a2079f1c57275a38cf3bf6d80 https://pubmed.ncbi.nlm.nih.gov/33672377 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4e1ceb2a2079f1c57275a38cf3bf6d80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14248247 |
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