Application of a point of care creatinine device for trend monitoring in kidney transplant patients: fit for purpose?
| العنوان: | Application of a point of care creatinine device for trend monitoring in kidney transplant patients: fit for purpose? |
|---|---|
| المؤلفون: | Ton J. M. Rövekamp, Anja Kessler, Fred P.H.T.M. Romijn, Paul J M van der Boog, Paul W. Schenk, Christa M. Cobbaert, Céline L van Lint, Ton J. Rabelink, Sandra van Dijk, Lothar Siekmann |
| المصدر: | Clinical Chemistry and Laboratory Medicine (CCLM), 53(10), 1547-1556 Clinical Chemistry and Laboratory Medicine, 10, 53, 1547-1556 |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Clinical Biochemistry, Kidney Function Tests, Isotopic dilution mass spectrometry, LS - Life Style, Kidney transplantation, chemistry.chemical_compound, Life, metrological traceability, Accuracy, Whole blood, Hematologic Tests, creatinine, General Medicine, Venous blood, Middle Aged, Health, Creatinine, Female, Healthy Living, Glomerular Filtration Rate, Human, Adult, medicine.medical_specialty, Capillary blood, reference standardization, Point-of-Care Systems, Urology, Renal function, kidney transplantation, Major clinical study, Kidney function, test purpose, medicine, Humans, Kidney dysfunction, Self-monitoring, Creatinine blood level, Laboratory device, Point of care, Monitoring, Physiologic, Metrological traceability, Test purpose, Mass spectrometry, business.industry, Intermethod comparison, Biochemistry (medical), Reproducibility of Results, self-monitoring, Reference standardization, medicine.disease, Surgery, Transplantation, chemistry, Creatinine Measurement, ELSS - Earth, Life and Social Sciences, Healthy for Life, business, Blood Chemical Analysis |
| الوصف: | Background: The StatSensor® Xpress-i™, a point-of-care system for blood creatinine measurement, offers patients the possibility of self-monitoring creatinine. In this study, the analytical performance of the StatSensor® for both detecting current renal function and monitoring renal (dys)function in kidney transplant patients was examined. Methods: Accuracy of the StatSensor® with capillary and venous whole blood was evaluated and compared to an isotopic dilution mass spectrometry (IDMS)-traceable enzymatic creatinine test in venous serum (n=138). Twenty Li-heparin samples were compared to the IDMS reference method performed by a Joint Committee for Traceability in Laboratory Medicine (JCTLM)-listed reference laboratory (RfB, Bonn, Germany). To evaluate StatSensor®'s suitability to monitor kidney function, both venous and capillary samples were obtained in 20 hospitalized transplantation patients. Venous samples were analyzed with an IDMS-traceable enzymatic test, capillary samples were measured using the StatSensor®. For all 2-day intervals, percentage change in creatinine was compared between both methods. Results: The StatSensor® did not meet total allowable error criterion of 6.9%. Average overall CVa for the StatSensor® was 10.4% and 5.2% for capillary and venous whole blood results, respectively. Overall CVa for the central laboratory serum creatinine method was |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1426b53f998b4e3ee539edd5f6bb67 http://hdl.handle.net/1887/100822 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4e1426b53f998b4e3ee539edd5f6bb67 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |