Effects of Growth Hormone and Insulin-Like Growth Factor I on Muscle in Mouse Models of Human Growth Disorders
| العنوان: | Effects of Growth Hormone and Insulin-Like Growth Factor I on Muscle in Mouse Models of Human Growth Disorders |
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| المؤلفون: | Stephanie M. Keeton, Ryan P. Clark, Mark D. Schuenke, Robert S. Staron, John J. Kopchick |
| المصدر: | Hormone Research in Paediatrics. 66:26-34 |
| بيانات النشر: | S. Karger AG, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Muscle Fibers, Skeletal, Growth hormone receptor, Biology, Growth hormone, Mice, Insulin-like growth factor, Endocrinology, Internal medicine, medicine, Animals, Humans, Growth factor receptor inhibitor, Insulin-Like Growth Factor I, Growth Disorders, Insulin-like growth factor 1 receptor, Mice, Knockout, Muscles, Growth factor, Direct effects, Phenotype, Disease Models, Animal, Growth Hormone, Pediatrics, Perinatology and Child Health, Carrier Proteins |
| الوصف: | The precise effects of growth hormone (GH) and insulin-like growth factor I (IGF-I) on muscle development and physiology are relatively unknown. Furthermore, there have been conflicting reports on the effects of GH/IGF-I on muscle. Distinguishing the direct effects of GH versus those of IGF-I is problematic, but animal models with altered GH/IGF-I action could help to alleviate some of the conflicting results and help to determine the independent actions of GH and IGF-I. The phenotypes of several mouse models, namely the GH receptor-gene-disrupted (GHR –/–) mouse and a variety of IGF-I –/– mice, are summarized, which ultimately will aid our understanding of this complex area. |
| تدمد: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000096620 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0cc8e2c4bb47dba269809226816b14 https://doi.org/10.1159/000096620 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4e0cc8e2c4bb47dba269809226816b14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16632826 16632818 |
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| DOI: | 10.1159/000096620 |