Surveillance for Transmissible Spongiform Encephalopathy in Scavengers of White-Tailed Deer Carcasses in the Chronic Wasting Disease Area of Wisconsin
| العنوان: | Surveillance for Transmissible Spongiform Encephalopathy in Scavengers of White-Tailed Deer Carcasses in the Chronic Wasting Disease Area of Wisconsin |
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| المؤلفون: | Daniel J. Barr, Cherrie A. Nolden, Edward A. Hoover, Joshua P. Vanderloo, Amir N. Hamir, Chad J. Johnson, Michael D. Samuel, Delwyn P. Keane, Christopher S. Jennelle, Judd M. Aiken |
| المصدر: | Journal of Toxicology and Environmental Health, Part A. 72:1018-1024 |
| بيانات النشر: | Informa UK Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Veterinary medicine, Insufficient Sample, Prions, animal diseases, Health, Toxicology and Mutagenesis, Population, Biology, Toxicology, Sensitivity and Specificity, Wisconsin, medicine, Animals, American mink, education, Mammals, education.field_of_study, Transmissible spongiform encephalopathy, Transmission (medicine), Deer, Brain, Chronic wasting disease, medicine.disease, biology.organism_classification, Virology, nervous system diseases, White (mutation), Population Surveillance, Wasting Disease, Chronic, Female, Reagent Kits, Diagnostic, Spongiform encephalopathy, Spleen |
| الوصف: | Chronic wasting disease (CWD), a class of neurodegenerative transmissible spongiform encephalopathies (TSE) occurring in cervids, is found in a number of states and provinces across North America. Misfolded prions, the infectious agents of CWD, are deposited in the environment via carcass remains and excreta, and pose a threat of cross-species transmission. In this study tissues were tested from 812 representative mammalian scavengers, collected in the CWD-affected area of Wisconsin, for TSE infection using the IDEXX HerdChek enzyme-linked immunosorbent assay (ELISA). Only four of the collected mammals tested positive using the ELISA, but these were negative when tested by Western blot. While our sample sizes permitted high probabilities of detecting TSE assuming 1% population prevalence in several common scavengers (93%, 87%, and 87% for raccoons, opossums, and coyotes, respectively), insufficient sample sizes for other species precluded similar conclusions. One cannot rule out successful cross-species TSE transmission to scavengers, but the results suggest that such transmission is not frequent in the CWD-affected area of Wisconsin. The need for further surveillance of scavenger species, especially those known to be susceptible to TSE (e.g., cat, American mink, raccoon), is highlighted in both a field and laboratory setting. |
| تدمد: | 1087-2620 1528-7394 |
| DOI: | 10.1080/15287390903084249 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b5b1034e3f89b4a97471252c8b1da https://doi.org/10.1080/15287390903084249 |
| رقم الانضمام: | edsair.doi.dedup.....4d2b5b1034e3f89b4a97471252c8b1da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10872620 15287394 |
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| DOI: | 10.1080/15287390903084249 |