Brain temperature and its fundamental properties: a review for clinical neuroscientists
| العنوان: | Brain temperature and its fundamental properties: a review for clinical neuroscientists |
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| المؤلفون: | Catherine Best, Rose Du, Kevin Spitler, Kevin S. Jackson, Bonnie H. Wang, Daniel A. Llano, Huan Wang, Matthew F. Sharrock, Claire M. Miller, Kieran P. Normoyle |
| المصدر: | Frontiers in Neuroscience, Vol 8 (2014) Frontiers in Neuroscience |
| بيانات النشر: | Frontiers Media SA, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Central Nervous System, Physiology, cerebral blood flow, Central nervous system, Review Article, Bioinformatics, lcsh:RC321-571, Epilepsy, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Stroke, Neonatal encephalopathy, Mechanism (biology), business.industry, General Neuroscience, Brain, temperature, Human brain, hyperthermia, medicine.disease, Review article, medicine.anatomical_structure, Cerebral blood flow, Thermal Regulation, hypothermia, business, Neuroscience |
| الوصف: | Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human diseases including: head trauma, stroke, multiple sclerosis, epilepsy, mood disorders, headaches, and neurodegenerative disorders, it is evident and well recognized that the therapeutic application of induced hypothermia is limited to a few highly selected clinical conditions such as cardiac arrest and hypoxic ischemic neonatal encephalopathy. Efforts to understand the fundamental aspects of brain temperature regulation are therefore critical for the development of safe, effective, and pragmatic clinical treatments for patients with brain injuries. Although centrally-mediated mechanisms to maintain a stable body temperature are relatively well established, very little is clinically known about brain temperature’s spatial and temporal distribution, its physiological and pathological fluctuations, and the mechanism underlying brain thermal homeostasis. The human brain, a metabolically expensive organ with intense heat production, is sensitive to fluctuations in temperature with regards to its functional activity and energy efficiency. In this review, we discuss several critical aspects concerning the fundamental properties of brain temperature from a clinical perspective. |
| تدمد: | 1662-453X |
| DOI: | 10.3389/fnins.2014.00307 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d10261a63e92b9349e4764b735812b8 https://doi.org/10.3389/fnins.2014.00307 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4d10261a63e92b9349e4764b735812b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1662453X |
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| DOI: | 10.3389/fnins.2014.00307 |