Involvement of the reward network is associated with apathy in cerebral small vessel disease
| العنوان: | Involvement of the reward network is associated with apathy in cerebral small vessel disease |
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| المؤلفون: | Lisiecka-Ford, Danuta M., Tozer, Daniel J., Morris, Robin G., Lawrence, Andrew J., Barrick, Thomas R., Markus, Hugh S. |
| المساهمون: | Tozer, Daniel [0000-0002-0404-3214], Markus, Hugh [0000-0002-9794-5996], Apollo - University of Cambridge Repository |
| المصدر: | Lisiecka Ford, D M, Tozer, D, Morris, R G, Lawrence, A J, Barrick, T R & Markus, H S 2018, ' Involvement of the reward network is associated with apathy in cerebral small vessel disease ', Journal of Affective Disorders . https://doi.org/10.1016/j.jad.2018.02.006 Journal of Affective Disorders |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | FSL, FMRIB Software Library, Male, small vessel disease, neural network, graph theory, Apathy, apathy, Article, Lacunar stroke, Reward, Humans, Cognitive Dysfunction, VTA, ventral tagmental area, AAL, Automated Anatomical Labelling, reward, Aged, Depressive Disorder, Depression, SVD, small vessel disease, GDS, Geriatric Depression Scale, Brain, WMH, white matter hyperintensities, lacunar stroke, SPGR, spoiled gradient recalled echo, Middle Aged, Magnetic Resonance Imaging, Neural network, Small vessel disease, Graph theory, Stroke, Diffusion Tensor Imaging, SCANS, St George's Cognition and Neuroimaging in Stroke, Cerebral Small Vessel Diseases, Female, DTI, diffusion tensor imaging, Nerve Net, MRI, magnetic resonance imaging |
| الوصف: | Introduction Apathy is a common yet under-recognised feature of cerebral small vessel disease (SVD), but its underlying neurobiological basis is not yet understood. We hypothesized that damage to the reward network is associated with an increase of apathy in patients with SVD. Methods In 114 participants with symptomatic SVD, defined as a magnetic resonance imaging confirmed lacunar stroke and confluent white matter hyperintensities, we used diffusion tensor imaging tractography to derive structural brain networks and graph theory to determine network efficiency. We determined which parts of the network correlated with apathy symptoms. We tested whether apathy was selectively associated with involvement of the reward network, compared with two “control networks” (visual and motor). Results Apathy symptoms negatively correlated with connectivity in network clusters encompassing numerous areas of the brain. Network efficiencies within the reward network correlated negatively with apathy scores; (r = − 0.344, p Highlights • Apathy is an important affective consequence of cerebral small vessel disease. • Our study investigates neuromechanism of apathy in small vessel disease. • We show that apathy is associated with structural disconnectivity in the reward network. |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| تدمد: | 1573-2517 |
| DOI: | 10.1016/j.jad.2018.02.006 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9d756ba313475b31d5c09a7116f8a9 https://openaccess.sgul.ac.uk/id/eprint/109713/1/PIIS0165032717323947.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4c9d756ba313475b31d5c09a7116f8a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732517 |
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| DOI: | 10.1016/j.jad.2018.02.006 |