Progression of emphysema evaluated by MRI using hyperpolarized 3he (hp 3he) measurements in patients with alpha-1-antitrypsin (a1at) deficiency compared with CT and lung function tests
| العنوان: | Progression of emphysema evaluated by MRI using hyperpolarized 3he (hp 3he) measurements in patients with alpha-1-antitrypsin (a1at) deficiency compared with CT and lung function tests |
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| المؤلفون: | Asger Dirksen, Laura M. Schreiber, M. Batz, Trine Stavngaard, L. Vejby Søgaard |
| المصدر: | Acta Radiologica. 50:1019-1026 |
| بيانات النشر: | SAGE Publications, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Percentile, Alpha (ethology), Pilot Projects, Helium, Pulmonary function testing, Isotopes, medicine, Humans, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, Reproducibility, Lung, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Respiratory disease, Reproducibility of Results, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Respiratory Function Tests, medicine.anatomical_structure, Pulmonary Emphysema, Disease Progression, Regression Analysis, Female, Tomography, X-Ray Computed, business, Nuclear medicine |
| الوصف: | Background: The progression of emphysema is traditionally measured by pulmonary function test, with forced expiratory volume in 1 s (FEV1) being the most accepted and used measurement. However, FEV1 is insensitive in detecting mild/slow progression of emphysema because of low reproducibility as compared to yearly decline. Purpose: To investigate the progression of emphysema over a period of 2 years using diffusion-weighted hyperpolarized (HP) 3He magnetic resonance imaging (MRI) in patients with alpha-1-antitrypsin (A1AT) deficiency. Material and Methods: Nine patients with severe A1AT deficiency were studied over a period of 2 years (baseline, year 1, and year 2) with HP 3He MRI using apparent diffusion coefficient (ADC), lung function tests (FEV1 and carbon monoxide lung diffusion capacity [DL,CO]), and computed tomography (CT) using densitometric parameters (15th percentile density [CT-PD15] and relative area of emphysema below -910 HU [CT-RA-910]). Results: Seven patients were scanned three times, one patient two times, and one patient only at baseline. The mean increase in ADC values from first to last HP 3He MR scanning was 3.8% (0.014 cm2/s [SD 0.024 cm2/s]; not significant). The time trends for FEV1, DL,CO, CT-PD15, and CT-RA-910 were all statistically significant. We found a high correlation between ADC and DL,CO ( P Conclusion: This pilot study indicates the possible use of nonionizing HP 3He MRI for monitoring the progression of emphysema. However, in the future, larger studies are needed to confirm these preliminary results. |
| تدمد: | 1600-0455 0284-1851 |
| DOI: | 10.3109/02841850903213822 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c60d21f362d7194c0f6cb64a0475929 https://doi.org/10.3109/02841850903213822 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4c60d21f362d7194c0f6cb64a0475929 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000455 02841851 |
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| DOI: | 10.3109/02841850903213822 |