The complement receptor 3, CR3 (CD11b/CD18), on T lymphocytes: activation-dependent up-regulation and regulatory function
| العنوان: | The complement receptor 3, CR3 (CD11b/CD18), on T lymphocytes: activation-dependent up-regulation and regulatory function |
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| المؤلفون: | Christof Wagner, Birgit Denefleh, Friederike Hug, Margarita Schoels, Sabine Stegmaier, G. Maria Hänsch |
| المصدر: | European Journal of Immunology. 31:1173-1180 |
| بيانات النشر: | Wiley, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | CD3 Complex, T-Lymphocytes, T cell, Immunology, Macrophage-1 Antigen, Biology, Ligands, Lymphocyte Activation, Antibodies, Cell Line, Mice, Interleukin 21, medicine, Animals, Humans, Immunology and Allergy, Cytotoxic T cell, Amino Acid Sequence, IL-2 receptor, Receptors, Immunologic, Antigen-presenting cell, Cells, Cultured, ZAP70, CD28, Complement C3, Flow Cytometry, Natural killer T cell, CD56 Antigen, Up-Regulation, Cell biology, medicine.anatomical_structure, Interleukin-2, Oligopeptides, Cell Division, T-Lymphocytes, Cytotoxic |
| الوصف: | The complement receptor 3 (CR3; CD11b/CD18) is present exclusively on leukocytes, particularly on NK cells, monocytes and polymorphonuclear neutrophils. Approximately 10% of peripheral T lymphocytes and, as we found now mainly CD8(+) cells, expressed CD11b. Upon stimulation, however, expression of CD11b was up-regulated also on CD4(+) cells. Stimulation of T cells either by cross-linked anti-CD3 and IL-2 or by mononuclear cells and mitogen yielded up to 28% CD11b(+) T cells. The majority of CD11b(+) T cells also expressed CD56. T cell lines established from healthy donors were also found to express CR3. When restimulated up to 90% of cells became positive for CD11b making those cells an ideal tool for studying the functional role of CD11b. Antibodies to CD11b and bona fide ligands for the complement receptor inhibited the anti-CD3-induced T cell proliferation and as well as IL-2 release. In contrast, proliferation of a CD11b(-) T cell line was not inhibited. Taken together, our data indicate an activation-dependent expression of the complement receptor on T cells and suggest a regulatory function. |
| تدمد: | 1521-4141 0014-2980 |
| DOI: | 10.1002/1521-4141(200104)31:4<1173::aid-immu1173>3.0.co;2-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be4347b2ce9eabcc442d653438682cb https://doi.org/10.1002/1521-4141(200104)31:4<1173::aid-immu1173>3.0.co;2-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4be4347b2ce9eabcc442d653438682cb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214141 00142980 |
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| DOI: | 10.1002/1521-4141(200104)31:4<1173::aid-immu1173>3.0.co;2-9 |