Synthesis and Characterization of Tunable Poly(Ethylene Glycol): Gelatin Methacrylate Composite Hydrogels
| العنوان: | Synthesis and Characterization of Tunable Poly(Ethylene Glycol): Gelatin Methacrylate Composite Hydrogels |
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| المؤلفون: | Hug Aubin, Hojae Bae, Jason W. Nichol, Che B. Hutson, Ali Khademhosseini, Shahed Al-Haque, Sandeep T. Koshy, Seda Yamanlar |
| المصدر: | Tissue Engineering Part A. 17:1713-1723 |
| بيانات النشر: | Mary Ann Liebert Inc, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | food.ingredient, Cell Survival, Surface Properties, Composite number, Biomedical Engineering, Bioengineering, macromolecular substances, complex mixtures, Biochemistry, Gelatin, Polyethylene Glycols, Biomaterials, Mice, 3D cell culture, chemistry.chemical_compound, food, PEG ratio, Cell Adhesion, Copolymer, Animals, Mechanical Phenomena, technology, industry, and agriculture, Water, Hydrogels, Original Articles, Fibroblasts, chemistry, Chemical engineering, Cell culture, Self-healing hydrogels, NIH 3T3 Cells, Methacrylates, Ethylene glycol |
| الوصف: | Poly(ethylene glycol) (PEG) hydrogels are popular for cell culture and tissue-engineering applications because they are nontoxic and exhibit favorable hydration and nutrient transport properties. However, cells cannot adhere to, remodel, proliferate within, or degrade PEG hydrogels. Methacrylated gelatin (GelMA), derived from denatured collagen, yields an enzymatically degradable, photocrosslinkable hydrogel that cells can degrade, adhere to and spread within. To combine the desirable features of each of these materials we synthesized PEG-GelMA composite hydrogels, hypothesizing that copolymerization would enable adjustable cell binding, mechanical, and degradation properties. The addition of GelMA to PEG resulted in a composite hydrogel that exhibited tunable mechanical and biological profiles. Adding GelMA (5%–15% w/v) to PEG (5% and 10% w/v) proportionally increased fibroblast surface binding and spreading as compared to PEG hydrogels (p |
| تدمد: | 1937-335X 1937-3341 |
| DOI: | 10.1089/ten.tea.2010.0666 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b90cb1b64ad28e4312e326edac811e9 https://doi.org/10.1089/ten.tea.2010.0666 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b90cb1b64ad28e4312e326edac811e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1937335X 19373341 |
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| DOI: | 10.1089/ten.tea.2010.0666 |