التفاصيل البيبلوغرافية
| العنوان: |
Orthohantaviruses, Emerging Zoonotic Pathogens |
| المؤلفون: |
Ekaterina V. Martynova, Anton F. Shamsutdinov, Richard A. Urbanowicz, Svetlana F. Khaiboullina, Ekaterina E. Garanina, T A Savitskaya, Guzel Isaeva, Yuriy N. Davidyuk, Sergey P. Morzunov, Cyprian Katongo, Emmanuel Kabwe, Albert A. Rizvanov, Kristina V. Kitaeva, Moffat Malisheni |
| المصدر: |
Pathogens
Pathogens, Vol 9, Iss 775, p 775 (2020) |
| بيانات النشر: |
MDPI, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Microbiology (medical), media_common.quotation_subject, Reassortment, lcsh:Medicine, Disease, Review, hantavirus pulmonary syndrome, Biology, Genome, Puumala orthohantavirus, hemorrhagic fever with renal syndrome, Nephropathia epidemica, medicine, Immunology and Allergy, HFRS and HPS, Molecular Biology, media_common, Hantavirus pulmonary syndrome, Genetic diversity, General Immunology and Microbiology, lcsh:R, Zoonosis, emerging, nephropathia epidemica, zoonosis, medicine.disease, recombination, Infectious Diseases, Evolutionary biology, reassortment, human activities, Diversity (politics) |
| الوصف: |
Orthohantaviruses give rise to the emerging infections such as of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) in Eurasia and the Americas, respectively. In this review we will provide a comprehensive analysis of orthohantaviruses distribution and circulation in Eurasia and address the genetic diversity and evolution of Puumala orthohantavirus (PUUV), which causes HFRS in this region. Current data indicate that the geographical location and migration of the natural hosts can lead to the orthohantaviruses genetic diversity as the rodents adapt to the new environmental conditions. The data shows that a high level of diversity characterizes the genome of orthohantaviruses, and the PUUV genome is the most divergent. The reasons for the high genome diversity are mainly caused by point mutations and reassortment, which occur in the genome segments. However, it still remains unclear whether this diversity is linked to the disease’s severity. We anticipate that the information provided in this review will be useful for optimizing and developing preventive strategies of HFRS, an emerging zoonosis with potentially very high mortality rates. |
| وصف الملف: |
PDF |
| اللغة: |
English |
| تدمد: |
2076-0817 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4a4ab40969a1dab7b9a7a5de9df91c |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....4b4a4ab40969a1dab7b9a7a5de9df91c |
| قاعدة البيانات: |
OpenAIRE |