Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport

التفاصيل البيبلوغرافية
العنوان: Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport
المؤلفون: Annemarie Poustka, Bernhard Korn, Horst Hameister, Dietmar Bächner, Zdenek Sedlacek
المصدر: Human molecular genetics. 4(4)
سنة النشر: 1995
مصطلحات موضوعية: DNA, Complementary, Gene Expression, Biology, Homology (biology), Embryonic and Fetal Development, Mice, GTP-binding protein regulators, GTP-Binding Proteins, Gene expression, Genetics, Animals, Humans, Northern blot, Amino Acid Sequence, Molecular Biology, Peptide sequence, Gene, Genetics (clinical), In Situ Hybridization, Guanine Nucleotide Dissociation Inhibitors, Base Sequence, Sequence Homology, Amino Acid, Rab GDP dissociation inhibitors, Biological Transport, General Medicine, Blotting, Northern, Biological Evolution, Cell biology, Rats, RNA, Cattle, Rab
الوصف: We have analysed the expression patterns of two human genes coding for two different rab GDIs, rab GDI alpha/XAP-4 and rab GDI beta, proteins involved in the regulation of vesicle-mediated cellular transport. The gene sequences are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms. Although the sequence homology between the two human rab GDIs studied is very high, their expression patterns are completely different. The Northern blot analysis and in situ hybridization to sections of mouse embryos and postnatal tissues have revealed that the rab GDI alpha/XAP-4 is expressed predominantly in neural and sensory tissues and may thus serve a specific function in neural signal transmission. In contrast to rab GDI alpha/XAP-4, the human rab GDI beta is expressed ubiquitously.
تدمد: 0964-6906
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae9951ea54663583449b52fa13a910b
https://pubmed.ncbi.nlm.nih.gov/7543319
رقم الانضمام: edsair.doi.dedup.....4ae9951ea54663583449b52fa13a910b
قاعدة البيانات: OpenAIRE