Evaluation of the safety of short-acting nifedipine in children with hypertension
| العنوان: | Evaluation of the safety of short-acting nifedipine in children with hypertension |
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| المؤلفون: | Douglas D Deming, David W. Egger, Ronald M. Perkin, Shobha Sahney, Norman Hamada |
| المصدر: | Pediatric Nephrology. 17:35-40 |
| بيانات النشر: | Springer Science and Business Media LLC, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Nephrology, medicine.medical_specialty, Adolescent, Nifedipine, Diastole, Blood Pressure, Oral administration, Internal medicine, medicine, Humans, Myocardial infarction, Child, Adverse effect, Retrospective Studies, Dose-Response Relationship, Drug, business.industry, Incidence (epidemiology), Infant, Calcium Channel Blockers, medicine.disease, Oxygen, Blood pressure, Child, Preschool, Anesthesia, Hypertension, Pediatrics, Perinatology and Child Health, Female, Hypotension, Nervous System Diseases, Safety, business, medicine.drug |
| الوصف: | Concerns regarding the safety of nifedipine emerged in 1995 with the report of an increased risk of myocardial infarction associated with adult patients receiving short-acting calcium channel blockers. There have been few case reports of adverse events in children. The purpose of this study is to investigate the effect on blood pressure (BP) and the incidence of adverse events associated with nifedipine in our pediatric population. We conducted a retrospective chart review of pediatric patients who received nifedipine. We recorded the dose administered, all BP measurements and all adverse events reported within six hours of a nifedipine dose regardless of the likelihood that those events were related to the nifedipine dose. 1,746 doses of nifedipine in 166 pediatric patients were reviewed. Systolic BP decreased by a mean of 17% and a maximum of 63%. Diastolic BP decreased by a mean of 28% and a maximum of 89%. Adverse events included: a) change in neurologic status, six cases; b) hypotension, two cases; c) oxygen desaturation, 16 cases. Neurologic events occurred in 33% of patients with acute CNS injury and 3.6% of all patients. Short-acting nifedipine is an important and effective oral antihypertensive agent which can be safely used for the treatment of hypertensive emergencies in children. It should be used with caution in children with acute CNS injury. |
| تدمد: | 1432-198X 0931-041X |
| DOI: | 10.1007/s004670200006 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a70f7397901d85e9346d7887a60d7a4 https://doi.org/10.1007/s004670200006 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4a70f7397901d85e9346d7887a60d7a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432198X 0931041X |
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| DOI: | 10.1007/s004670200006 |