Characterization of Orodispersible Films: An Overview of Methods and Introduction to a New Disintegration Test Apparatus Using LDR - LED Sensors

التفاصيل البيبلوغرافية
العنوان: Characterization of Orodispersible Films: An Overview of Methods and Introduction to a New Disintegration Test Apparatus Using LDR - LED Sensors
المؤلفون: Tegginamath Pramod Kumar, Maram Suresh Gupta
المصدر: Journal of Pharmaceutical Sciences. 109:2925-2942
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Computer science, Chemistry, Pharmaceutical, Drug Compounding, media_common.quotation_subject, Administration, Oral, Pharmaceutical Science, Orodispersible film, Capsules, 02 engineering and technology, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, Poor quality, Characterization (materials science), Reliability engineering, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Solubility, Swallowing problems, Research community, Humans, Quality (business), 0210 nano-technology, Tablets, media_common
الوصف: Orodispersible Film (ODF) is a promising and progressive dosage form that offers exceptional drug delivery benefits to patients. Indeed, they are the most transformational alternatives to traditional/conventional dosage forms such as tablets and capsules. ODFs are portable and highly comfortable for self-administration by patients with swallowing problems. The key to gain end-user acceptance is to have an ODF with outstanding quality. Poor quality may lead to choking or spitting, accordingly leading to a lack of compliance. It is vital to employ suitable experimental methodologies that facilitate characterization or determination of the quality of ODF. Nonetheless, there are no standard techniques prescribed in official compendia of any country. But, there is a consensus in the thin-film research community about the characterization techniques that one relies on deciding the quality of an ODF. We review various experimental techniques and highlight its importance in determining the performance and quality of an ODF. We provide a relatively novel and inventive disintegration test apparatus, which works using ‘Light Dependent Resistor (LDR) and Light Emitting Diode (LED) sensors’ for clear and accurate determination of start and end disintegration time of an ODF.
تدمد: 0022-3549
DOI: 10.1016/j.xphs.2020.06.012
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6d5eed64737fd488f2952e597f6bb2
https://doi.org/10.1016/j.xphs.2020.06.012
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....4a6d5eed64737fd488f2952e597f6bb2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00223549
DOI:10.1016/j.xphs.2020.06.012