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The Histamine H2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine

التفاصيل البيبلوغرافية
العنوان: The Histamine H2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
المؤلفون: Taeko Yonekawa, Koichi Ueno, Shingo Yano, Tomonori Nakamura, Katsunori Yamaura
المصدر: Journal of Pharmacological Sciences, Vol 92, Iss 1, Pp 43-49 (2003)
بيانات النشر: Elsevier, 2003.
سنة النشر: 2003
مصطلحات موضوعية: Cartilage, Articular, medicine.medical_specialty, Mepyramine, Arthritis, Osteoclasts, Histamine Agonists, chemistry.chemical_compound, In vivo, Osteoclast, Bone Density, Dimaprit, Internal medicine, medicine, Animals, Cimetidine, Bone Resorption, Pharmacology, Pyrilamine, lcsh:RM1-950, Cell Differentiation, medicine.disease, Arthritis, Experimental, Rats, Osteopenia, Endocrinology, medicine.anatomical_structure, lcsh:Therapeutics. Pharmacology, chemistry, Histamine H2 Antagonists, Rats, Inbred Lew, Histamine H1 Antagonists, Molecular Medicine, Female, Histamine, medicine.drug
الوصف: The effects of cimetidine on rat adjuvant arthritis (AA) and rat osteoclast differentiation were studied. For the in vivo experiments, AA was induced by injections of Mycobacterium tuberculosis H37RA either subcutaneously into the base of the tail or into the right hind paw. The osteoclast differentiation was assessed by estimating the number of tartrate-resistant acid phosphatase-positive multinuclear cells in the bone marrow culture. Cimetidine, at the dose of 25 mg/kg body weight, reduced the paw swelling by 70% (P
اللغة: English
تدمد: 1347-8613
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2f657bfb1956b9070dd1546e166ecd
http://www.sciencedirect.com/science/article/pii/S1347861319326945
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....4a2f657bfb1956b9070dd1546e166ecd
قاعدة البيانات: OpenAIRE
الوصف
تدمد:13478613