CD4 + T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors
| العنوان: | CD4 + T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors |
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| المؤلفون: | Jessica N. Hodge, Leonid Margolis, Sarah W. Read, Stephen A. Migueles, Philip I. Lee, Stephen B. Kovacs, Jamieson H. Greenwald, Irini Sereti, Emily J. Ciccone, Cheryl Chairez, William L. Thompson, Michael A. Yao, Joseph A. Kovacs, Angelique Biancotto |
| المصدر: | Journal of Virology. 85:5880-5888 |
| بيانات النشر: | American Society for Microbiology, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, T cell, Immunology, Population, HIV Infections, Biology, medicine.disease_cause, Microbiology, HIV Long-Term Survivors, Immunophenotyping, Immunity, Virology, medicine, Humans, Intestinal Mucosa, education, Immunity, Mucosal, education.field_of_study, Monocyte, Middle Aged, Simian immunodeficiency virus, Ki-67 Antigen, medicine.anatomical_structure, Mucosal immunology, Insect Science, HIV-1, Th17 Cells, Pathogenesis and Immunity, Viral load |
| الوصف: | During acute human immunodeficiency virus (HIV) infection, there is a massive depletion of CD4 + T cells in the gut mucosa that can be reversed to various degrees with antiretroviral therapy. Th17 cells have been implicated in mucosal immunity to extracellular bacteria, and preservation of this subset may support gut mucosal immune recovery. However, this possibility has not yet been evaluated in HIV-1-infected long-term nonprogressors (LTNPs), who maintain high CD4 + T cell counts and suppress viral replication in the absence of antiretroviral therapy. In this study, we evaluated the immunophenotype and function of CD4 + T cells in peripheral blood and gut mucosa of HIV-uninfected controls, LTNPs, and HIV-1-infected individuals treated with prolonged antiretroviral therapy (ART) (VL [viral load]+ T cell populations, including Th17 and cycling subsets, in the gut mucosa and a preserved T cell population expressing gut homing molecules in the peripheral blood. In addition, we observed no evidence of higher monocyte activation in LTNPs than in HIV-infected (HIV − ) controls. These data suggest that, similar to nonpathogenic simian immunodeficiency virus (SIV) infection, LTNPs preserve the balance of CD4 + T cell populations in blood and gut mucosa, which may contribute to the lack of disease progression observed in these patients. |
| تدمد: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.02643-10 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a18efba911165fdd435e21740610684 https://doi.org/10.1128/jvi.02643-10 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4a18efba911165fdd435e21740610684 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985514 0022538X |
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| DOI: | 10.1128/jvi.02643-10 |