Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8
| العنوان: | Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8 |
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| المؤلفون: | Hans Moldenhauer, Juan P. Castillo, Ramon Latorre, Osvaldo Alvarez, Willy Carrasquel-Ursulaez |
| المصدر: | Temperature: Multidisciplinary Biomedical Journal |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Trpm8 channel, Physiology, Chemistry, R, universal gas constant, H0, Standard molar enthalpy, F, Faraday, Priority Review, SUPERFAMILY, T, temperature, Q10, temperature coefficient, DRG, dorsal root ganglion, TG, trigeminal ganglion, Transient receptor potential channel, G0, Standard molar Gibbs free energy, S0, Standard molar entropy, Physiology (medical), Cold receptor, TRPM8, Biophysics, Critical assessment, Ion channel, TRP, transient receptor potential |
| الوصف: | Mammals maintain homeostatic control of their body temperature. Therefore, these organisms are expected to have adaptations that confer the ability to detect and react to both self and ambient temperature. Temperature-activated ion channels have been discovered to be the primary molecular determinants of thermosensation. The most representative group of these determinants constitutes members of the transient receptor potential superfamily, TRP, which are activated by either low or high temperatures covering the whole range of physiologically relevant temperatures. This review makes a critical assessment of existing analytical methods of temperature-activated TRP channel mechanisms using the cold-activated TRPM8 channel as a paradigm. |
| تدمد: | 2332-8959 2332-8940 |
| DOI: | 10.1080/23328940.2015.1047558 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fb6173a77f809fd58a06d48493eeca https://doi.org/10.1080/23328940.2015.1047558 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....49fb6173a77f809fd58a06d48493eeca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23328959 23328940 |
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| DOI: | 10.1080/23328940.2015.1047558 |