High-dose cytosine arabinoside and mitoxantrone in previously-treated acute leukemia patients
| العنوان: | High-dose cytosine arabinoside and mitoxantrone in previously-treated acute leukemia patients |
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| المؤلفون: | Y. Carcassonne, G. Sebahoun, C. Lejeune, M. C. Launay, Dominique Maraninchi, N. Tubiana, Danielle Sainty, Jean-Louis Gastaut, Bruno Richard |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Acute myeloblastic leukemia, medicine.medical_treatment, Blastic Phase, Gastroenterology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Infusions, Intravenous, Aged, Chemotherapy, Mitoxantrone, Acute leukemia, Dose-Response Relationship, Drug, business.industry, Cytarabine, Hematology, General Medicine, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, Anesthesia, Female, business, medicine.drug, Chronic myelogenous leukemia |
| الوصف: | 35 patients with refractory or relapsed acute leukemia received salvage chemotherapy using high-dose cytosine arabinoside 2 g/m2 intravenously for 3 hours every 12 h, in 8 doses, followed by continuous infusion of mitoxantrone 12 mg/m2/day for 2 d. 9 patients had acute myeloblastic leukemia (AML), (4 relapsed, 5 refractory), 20 had acute lymphoblastic leukemia (ALL) (11 relapsed, 9 refractory) and 6 had chronic myelogenous leukemia (CML) in the blastic phase (BP). 4 out of 9 AML and 16 out of 20 ALL achieved complete remission. Median survival was 6 months for all patients and 10 months for responders. A short (1.5 months) chronic phase was achieved in 3 patients with CML. The main toxic effect was hematologic. A pharmacokinetic study was performed on mitoxantrone. No correlation was found with clinical response. The combination of mitoxantrone and ara-C is an effective antileukemic regimen, especially in ALL. |
| تدمد: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.1990.tb00386.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ac2aee02597cb684cd676315fe6bfd https://doi.org/10.1111/j.1600-0609.1990.tb00386.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....49ac2aee02597cb684cd676315fe6bfd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000609 09024441 |
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| DOI: | 10.1111/j.1600-0609.1990.tb00386.x |