Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy
| العنوان: | Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy |
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| المؤلفون: | Liza S. Köster, Anne French, Inigo Sanz-Gonzalez, Peter David Eckersall, Christopher C. Chadwick, P. R. Wotton, Mengmeng Liu, Geoffrey T. Fosgate |
| المصدر: | Journal of Veterinary Internal Medicine, Vol 34, Iss 3, Pp 1078-1090 (2020) Journal of Veterinary Internal Medicine |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Cardiomyopathy, Standard Article, 030204 cardiovascular system & hematology, Cat Diseases, NT‐proBNP, 0403 veterinary science, feline cardiomyopathy, chemistry.chemical_compound, 0302 clinical medicine, Natriuretic Peptide, Brain, SDMA, Natriuretic peptide, CATS, lcsh:Veterinary medicine, 04 agricultural and veterinary sciences, LRG1, Standard Articles, SAA, ceruloplasmin, Creatinine, cardiovascular system, Cardiology, biomarker, Female, Kidney Diseases, acute‐phase protein, Cardiomyopathies, medicine.medical_specialty, 040301 veterinary sciences, medicine.drug_class, Renal function, Cardiorenal syndrome, Arginine, Primary cardiomyopathy, 03 medical and health sciences, Internal medicine, medicine, Animals, cardiovascular diseases, Heart Failure, Inflammation, cardiorenal syndrome, General Veterinary, business.industry, AGP, medicine.disease, Peptide Fragments, chemistry, Heart failure, Case-Control Studies, Cats, lcsh:SF600-1100, SMALL ANIMAL, business, Biomarkers, Acute-Phase Proteins |
| الوصف: | Background Currently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood. Objective To identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly related to cardiovascular-renal axis disorder and systemic inflammatory response. Animals Twenty-five cats in CHF caused by primary cardiomyopathy, 12 cats with preclinical cardiomyopathy, and 20 healthy controls. Methods Case control and observational case series. The following serum biomarkers were compared among the 3 cat groups: a cardiorenal profile that included N-terminal pro-brain natriuretic peptide (NT-proBNP), symmetric dimethylarginine (SDMA), and creatinine and an inflammatory profile that included 7 acute-phase proteins (APPs). Survival analyses and longitudinal studies were performed in CHF cats. Results All cardiorenal biomarkers were positively correlated and higher in CHF cats, and high NT-proBNP and SDMA were associated with poor clinical outcome. Cats with CHF had significantly higher leucine-rich alpha-2-glycoprotein 1, serum amyloid A, and ceruloplasmin, and these APPs were positively correlated with NT-proBNP and left atrial size. In a multivariable survival analysis, alpha-1-acid glycoprotein concentration (P = .01), body weight (P = .02) and left atrial-to-aortic root ratio (P = .01) were independent prognostic factors for CHF in these cats. Conclusions and clinical importance In cats, CHF is an inflammatory disorder and outcome in CHF may be determined by the extent of inflammation and possibly the amount of residual renal function. These novel biomarkers have potential use for the clinical management, prognosis, and future research into CHF and cardiomyopathy in cats. |
| اللغة: | English |
| تدمد: | 0891-6640 1939-1676 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4918116d5b669a880f8c0fdd7d77ae31 https://doaj.org/article/c86ccd0d27e147ccb4704f0c394ae896 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4918116d5b669a880f8c0fdd7d77ae31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08916640 19391676 |
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