Platelet Activity in Migraine
| العنوان: | Platelet Activity in Migraine |
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| المؤلفون: | Giovanni D' Andrea, Moreno Toldo, S Cortelazzo, Francesco Ferro Milone |
| المصدر: | Headache: The Journal of Head and Face Pain. 22:207-212 |
| بيانات النشر: | Wiley, 1982. |
| سنة النشر: | 1982 |
| مصطلحات موضوعية: | Adult, Blood Platelets, Serotonin, medicine.medical_specialty, Migraine Disorders, Platelet Factor 4, Basal (phylogenetics), In vivo, Internal medicine, medicine, Humans, Platelet, Platelet activation, 5-HT receptor, business.industry, Plasma levels, Middle Aged, beta-Thromboglobulin, medicine.disease, Endocrinology, Neurology, Migraine, Anesthesia, Female, Neurology (clinical), business |
| الوصف: | SYNOPSIS Migraine is a disease associated with increased platelet activity. The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta-thromboglobulin (B-TG) and platelet factor four (PF4) plasma levels, in headache-free-periods and during migraine attacks. In headache-free-periods, there was no differences in platelet 5HT values between migraine patients and control subjects. On the other hand, there were significant differences in B-TG and PF4 plasma levels. Furthermore, two groups of migraine patients were observed, one with normal B-TG plasma levels and the other with high B-TG plasma levels. PF4 plasma levels behave similarly. During migraine attacks, platelet 5-HT fell, while B-TG and PF4 plasma levels rose, if compared to the values recorded immediately before attacks. We suggest that migraine patients, particularly those ones with high basal values of B-TG and PF4 plasma levels, form a high risk group to cerebrovascular ischaemic diseases. For these patients a prophylaxis with antiplatelet drugs is indicated. |
| تدمد: | 1526-4610 0017-8748 |
| DOI: | 10.1111/j.1526-4610.1982.hed2205207.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4896766430aef86a290669e29c827319 https://doi.org/10.1111/j.1526-4610.1982.hed2205207.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4896766430aef86a290669e29c827319 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15264610 00178748 |
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| DOI: | 10.1111/j.1526-4610.1982.hed2205207.x |