Molecular docking of potential inhibitors with the mTOR protein
| العنوان: | Molecular docking of potential inhibitors with the mTOR protein |
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| المؤلفون: | Rajagopal Ponnulakshmi, Venkatacalam Sivabalan, Malathi Kullappan, Jayaraman Selvaraj, Umapathy Vidhya Rekha, Surapaneni Krishna Mohan, Veeraraghavan Vishnupriya, Radhika Nalinakumari Sreekandan, Jh Shazia Fathima, Periyasamy Vijayalakshmi |
| المصدر: | Bioinformation |
| بيانات النشر: | Biomedical Informatics, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | biology, Chemistry, MTOR Protein, Cancer, General Medicine, molecular docking, oral cancer, medicine.disease, Approved drug, chemistry.chemical_compound, paclitaxel, Paclitaxel, Cancer research, biology.protein, medicine, mTOR, Mechanistic target of rapamycin, analogues, PI3K/AKT/mTOR pathway, Research Article |
| الوصف: | The mTOR (mammalian or mechanistic Target of Rapamycin) is linked with oral cancer. Therefore, it is of interest to study the molecular docking-based binding of paclitaxel (a FDA approved drug for oral cancer) and its analogues with mTOR. Hence, we report the binding features of 10-Deacetyltaxol, 7-Epi-10-deacetyltaxol, 7-Epi-Taxol and 6alpha-Hydroxypaclitaxel with mTOR for further consideration. |
| اللغة: | English |
| تدمد: | 0973-2063 0973-8894 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481553eed664204d667332f32662fb52 http://europepmc.org/articles/PMC8340694 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....481553eed664204d667332f32662fb52 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09732063 09738894 |
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