Syndecan-1 Expression in Gallbladder Cancer and Its Prognostic Significance
| العنوان: | Syndecan-1 Expression in Gallbladder Cancer and Its Prognostic Significance |
|---|---|
| المؤلفون: | Y.H. Kim, Young Hoon Roh, H.J. Choi, M.S. Roh, K.E. Lee |
| المصدر: | European Surgical Research. 41:245-250 |
| بيانات النشر: | S. Karger AG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Prognostic factor, animal structures, Kaplan-Meier Estimate, Syndecan 1, Predictive Value of Tests, Biomarkers, Tumor, medicine, Humans, Gallbladder cancer, Aged, Aged, 80 and over, business.industry, Gallbladder, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, carbohydrates (lipids), medicine.anatomical_structure, embryonic structures, Female, Gallbladder Neoplasms, Surgery, Syndecan-1, business |
| الوصف: | Aim: To determine whether the immunohistochemical detection of syndecan-1 could provide useful information as a novel therapeutic or prognostic factor in primary gallbladder (GB) cancer. Materials and Methods: Forty-three GB cancer tissues were evaluated by immunohistochemistry for syndecan-1 expression. The relationship between syndecan-1 expression and clinicopathological characteristics, and the univariate survival analysis for the influence of the syndecan-1 expression on the overall survival were analysed. Results: Epithelial syndecan-1 immunoreactivity was observed in 25 (58.1%) of the 43 GB cancer cases. The tumors with a positive syndecan-1 expression more frequently showed lymph node metastasis (p = 0.037). Although there was no statistically significant association, the tumors with a positive syndecan-1 expression tended to show a deeper invasion depth (p = 0.087) and more frequent lymphovascular invasion (p = 0.064). The Kaplan-Meier survival curves demonstrated that patients with positive syndecan-1 expression had a significantly shorter survival time than those patients with negative syndecan-1 expression (p = 0.05). Conclusions: A subset of GB cancers revealed an epithelial overexpression of syndecan-1, which was associated with a progressive pathological feature and an aggressive clinical course. Therefore, epithelial syndecan-1 expression may be a predictor for a poor prognosis in patients with GB cancer. |
| تدمد: | 1421-9921 0014-312X |
| DOI: | 10.1159/000137667 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47dd56471b69e9e40eea060b2af9c312 https://doi.org/10.1159/000137667 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....47dd56471b69e9e40eea060b2af9c312 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219921 0014312X |
|---|---|
| DOI: | 10.1159/000137667 |