Iron Deficiency in Inflammatory Bowel Disease: The Use of Zincprotoporphyrin and Red Blood Cell Distribution Width
| العنوان: | Iron Deficiency in Inflammatory Bowel Disease: The Use of Zincprotoporphyrin and Red Blood Cell Distribution Width |
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| المؤلفون: | Frank Brus, Joachim J. Schweizer, Johannes B. van Goudoever, Anemone van den Berg, Daniëlle Hendriks, Mirjam Vreugdenhil, Marjolijn D. Akkermans |
| المساهمون: | Amsterdam Reproduction & Development (AR&D), AGEM - Endocrinology, metabolism and nutrition, ACS - Diabetes & metabolism, Pediatric surgery, Neonatology, General Paediatrics, Amsterdam Gastroenterology Endocrinology Metabolism |
| المصدر: | Journal of Pediatric Gastroenterology and Nutrition, 64(6), 949-954. Lippincott Williams and Wilkins Akkermans, M D, Vreugdenhil, M, Hendriks, D M, Van Den Berg, A, Schweizer, J J, Van Goudoever, J B & Brus, F 2017, ' Iron Deficiency in Inflammatory Bowel Disease : The Use of Zincprotoporphyrin and Red Blood Cell Distribution Width ', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, no. 6, pp. 949-954 . https://doi.org/10.1097/MPG.0000000000001406 Journal of pediatric gastroenterology and nutrition, 64(6), 949-954. Lippincott Williams and Wilkins Journal of Pediatric Gastroenterology and Nutrition, 64(6), 949-954 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Erythrocyte Indices, Male, medicine.medical_specialty, Pathology, Adolescent, Anemia, Protoporphyrins, Inflammation, Inflammatory bowel disease, Gastroenterology, Diagnosis, Differential, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, inflammatory bowel disease, Risk Factors, Internal medicine, iron-restricted erythropoiesis, medicine, Prevalence, Humans, Child, Anemia, Iron-Deficiency, business.industry, Zinc protoporphyrin, Inflammatory Bowel Diseases, functional iron deficiency, Red blood cell distribution width, Iron deficiency, medicine.disease, digestive system diseases, zinc protoporphyrin, Cross-Sectional Studies, chemistry, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, absolute iron deficiency, Multivariate Analysis, 030211 gastroenterology & hepatology, Female, medicine.symptom, Differential diagnosis, red blood cell distribution width, business, Biomarkers |
| الوصف: | Objectives: Iron deficiency (ID) in children with inflammatory bowel disease (IBD) is either an absolute (depleted iron stores) or a functional deficiency (caused by chronic inflammation). Differentiating between these 2 types of ID is important because they require a different therapeutic approach. Zinc protoporphyrin (ZPP) and red blood cell distribution width (RDW) are parameters of functional ID. Studies using these parameters to differentiate are nonexistent. We aimed to evaluate the prevalence of and risk factors for absolute and functional ID in paediatric IBD patients while using ZPP and RDW. Methods: We evaluated the iron status and medical charts of 59 paediatric IBD patients in a secondary hospital in the Netherlands. Absolute ID was defined as serum ferritin 70 μmol/mol haem and/or an RDW >14%. Anaemia of chronic disease (ACD) was defined as functional ID in combination with anaemia. Results: Absolute and functional ID were found in 19/59 (32.2%) and 32/40 (80%) patients, respectively. The prevalence of IDA and ACD was 27.1% (16/59) and 20% (8/40), respectively. Multivariate analyses showed that absolute ID and IDA were both associated with a more recent IBD-diagnosis (both P < 0.05). Conclusions: Absolute and functional ID are common in paediatric IBD patients, and this differentiation is important because of therapeutic consequences. Furthermore, absolute ID and IDA are associated with a more recent IBD-diagnosis. |
| اللغة: | English |
| تدمد: | 0277-2116 |
| DOI: | 10.1097/MPG.0000000000001406 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4783a6d70b3cf20c323e07eb980d21aa https://research.vumc.nl/en/publications/5a29170c-b15f-4590-867c-81d5216765e6 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....4783a6d70b3cf20c323e07eb980d21aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02772116 |
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| DOI: | 10.1097/MPG.0000000000001406 |