Cardiovascular Diseases in Obesity: What is the Role of Magnesium?
| العنوان: | Cardiovascular Diseases in Obesity: What is the Role of Magnesium? |
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| المؤلفون: | Gilberto Simeone Henriques, Thayanne Gabryelle Visgueira de Sousa, Mickael de Paiva Sousa, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Lyandra Dias da Silva, Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Dilina do Nascimento Marreiro |
| المصدر: | Biological Trace Element Research. 199:4020-4027 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Adipose tissue, chemistry.chemical_element, 010501 environmental sciences, Reductase, 01 natural sciences, Biochemistry, Inorganic Chemistry, 03 medical and health sciences, Nutrient, Internal medicine, medicine, Humans, Magnesium, Obesity, Triglycerides, Dyslipidemias, 0105 earth and related environmental sciences, 0303 health sciences, Lipoprotein lipase, business.industry, 030302 biochemistry & molecular biology, Biochemistry (medical), Lipid metabolism, General Medicine, medicine.disease, Endocrinology, chemistry, Cardiovascular Diseases, Acyltransferase, lipids (amino acids, peptides, and proteins), business |
| الوصف: | An excess of adipose tissue, a characteristic of obesity, has been associated with endocrine-metabolic alterations that contribute to dyslipidemias, which are characterized by an increase in the plasma concentrations of triacylglycerols, total cholesterol, and LDL-c along with a reduction in HDL-c. Some nutrients such as the mineral magnesium play important roles in lipid metabolism. Magnesium regulates the activity of HMG-CoA reductase, increasing the activity of lipoprotein lipase and lecithin-cholesterol acyltransferase. The objective of this review is to present important aspects about the contribution of obesity to the manifestation of cardiovascular risk, to bring the main physiological functions of magnesium, as well as the role of the nutrient in the protection against cardiovascular diseases. Studies have shown that individuals with obesity have low intracellular concentrations of magnesium, which can compromise the nutrient's physiological functions. Thus, this mineral appears to play an important role in protecting against cardiovascular diseases; however, changes in the nutrient metabolism in obesity may compromise the functions of this element. Further studies are needed to clarify this. |
| تدمد: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-020-02528-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469d901da2f34bba8e76c0332e152781 https://doi.org/10.1007/s12011-020-02528-7 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....469d901da2f34bba8e76c0332e152781 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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| DOI: | 10.1007/s12011-020-02528-7 |