Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization
| العنوان: | Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization |
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| المؤلفون: | Jerome J. Lacroix, Francisco Bezanilla, Dirk J. Snyders, Michael F. Priest, Alain J. Labro |
| المصدر: | NATURE COMMUNICATIONS Nature communications Nature Communications |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Models, Molecular, CNS NEURONS, Patch-Clamp Techniques, Refractory period, GATING CURRENTS, Xenopus, Action Potentials, General Physics and Astronomy, Nerve Tissue Proteins, Article, General Biochemistry, Genetics and Molecular Biology, S3-S4 LINKER, VOLTAGE SENSITIVITY, Medicine and Health Sciences, Animals, Humans, Repolarization, Patch clamp, CEREBELLAR PURKINJE NEURONS, Biology, KV3.1 POTASSIUM CHANNEL, SODIUM CURRENT, Neurons, Multidisciplinary, Biology and Life Sciences, Cardiac action potential, SUBUNIT KV3.1B, General Chemistry, Ether-A-Go-Go Potassium Channels, Markov Chains, Chemistry, Membrane repolarization, Shaw Potassium Channels, Transmission (telecommunications), Oocytes, Potassium, Biophysics, INACTIVATION, Human medicine, SHAKER, Engineering sciences. Technology, Communication channel |
| الوصف: | High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast closure kinetics, which reduce the neuron's refractory period. However, premature Kv3 channel closure leads to incomplete membrane repolarization, preventing sustainable AP propagation. Here, we demonstrate that Kv3.1b channels solve this problem by producing resurgent K+ currents during repolarization, thus ensuring enough repolarizing power to terminate each AP. Unlike previously described resurgent Na+ and K+ currents, Kv3.1b's resurgent current does not originate from recovery of channel block or inactivation but results from a unique combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation. These distinct properties are readily transferrable onto an orthologue Kv channel by transplanting the voltage-sensor's S3–S4 loop, providing molecular insights into the mechanism by which Kv3 channels contribute to high-frequency AP transmission. Kv3 potassium channels have an important role in the repolarization of action potentials in fast-spiking neurons. Here, the authors use electrophysiology and modelling to report on an interesting mechanism that might explain their gating behaviour. |
| وصف الملف: | application/pdf; pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466f9a82968206a08977487f0271a41b https://hdl.handle.net/1854/LU-8704924 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....466f9a82968206a08977487f0271a41b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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