Defining a metabolic landscape of tumours: genome meets metabolism
| العنوان: | Defining a metabolic landscape of tumours: genome meets metabolism |
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| المؤلفون: | Sharavan Vishaan Venkateswaran, Chandan Seth Nanda, Neill Patani, Mariia Yuneva |
| المصدر: | Br J Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, Carcinogenesis, Inflammation, Computational biology, Biology, medicine.disease_cause, Genome, Article, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, Humans, Gene, 030304 developmental biology, Epigenomics, 0303 health sciences, Genome, Human, Genetic heterogeneity, 3. Good health, Crosstalk (biology), Oncology, 030220 oncology & carcinogenesis, medicine.symptom, Signal Transduction |
| الوصف: | Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic, transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in cancer initiation, progression and evolution is well understood. However, although metabolic changes in cancer have long been acknowledged and considered a plausible therapeutic target, the crosstalk between genetic and metabolic alterations throughout cancer types is not clearly defined. In this review, we summarise the present understanding of the interactions between genetic drivers of cellular transformation and cancer-associated metabolic changes, and how these interactions contribute to metabolic heterogeneity of tumours. We discuss the essential question of whether changes in metabolism are a cause or a consequence in the formation of cancer. We highlight two modes of how metabolism contributes to tumour formation. One is when metabolic reprogramming occurs downstream of oncogenic mutations in signalling pathways and supports tumorigenesis. The other is where metabolic reprogramming initiates transformation being either downstream of mutations in oncometabolite genes or induced by chronic wounding, inflammation, oxygen stress or metabolic diseases. Finally, we focus on the factors that can contribute to metabolic heterogeneity in tumours, including genetic heterogeneity, immunomodulatory factors and tissue architecture. We believe that an in-depth understanding of cancer metabolic reprogramming, and the role of metabolic dysregulation in tumour initiation and progression, can help identify cellular vulnerabilities that can be exploited for therapeutic use. |
| تدمد: | 1532-1827 0007-0920 |
| DOI: | 10.1038/s41416-019-0663-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fce76c301a62dbbcae4cc6caf2e576 https://doi.org/10.1038/s41416-019-0663-7 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....45fce76c301a62dbbcae4cc6caf2e576 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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| DOI: | 10.1038/s41416-019-0663-7 |