Rapid and reversible control of human metabolism by individual sleep states
| العنوان: | Rapid and reversible control of human metabolism by individual sleep states |
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| المؤلفون: | Stefan Bauer, Malcolm Kohler, Ricards Marcinkevics, Nora Nowak, Pablo Martinez-Lozano Sinues, Martin Osswald, Thomas Gaisl, Renato Zenobi, Steven A. Brown, Joachim M. Buhmann, Djordje Miladinovic |
| المساهمون: | University of Zurich |
| المصدر: | Cell Reports, 37 (4) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Spectrometry, Mass, Electrospray Ionization, Metabolite, Citric Acid Cycle, Rapid eye movement sleep, Sleep, REM, 10050 Institute of Pharmacology and Toxicology, 610 Medicine & health, Genetics and Molecular Biology, Polysomnography, Sleep, Slow-Wave, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Metabolomics, Metabolome, medicine, Humans, Beta oxidation, Sleep restriction, medicine.diagnostic_test, Lipid Metabolism, Sleep in non-human animals, chemistry, General Biochemistry, 570 Life sciences, biology, Female, Neuroscience |
| الوصف: | Sleep is crucial to restore body functions and metabolism across nearly all tissues and cells, and sleep restriction is linked to various metabolic dysfunctions in humans. Using exhaled breath analysis by secondary electrospray ionization high-resolution mass spectrometry, we measured the human exhaled metabolome at 10-s resolution across a night of sleep in combination with conventional polysomnography. Our subsequent analysis of almost 2,000 metabolite features demonstrates rapid, reversible control of major metabolic pathways by the individual vigilance states. Within this framework, whereas a switch to wake reduces fatty acid oxidation, a switch to slow-wave sleep increases it, and the transition to rapid eye movement sleep results in elevation of tricarboxylic acid (TCA) cycle intermediates. Thus, in addition to daily regulation of metabolism, there exists a surprising and complex underlying orchestration across sleep and wake. Both likely play an important role in optimizing metabolic circuits for human performance and health. Cell Reports, 37 (4) ISSN:2666-3864 ISSN:2211-1247 |
| وصف الملف: | 2021_Cell_Rep._Novak_et_al.pdf - application/pdf; application/application/pdf |
| اللغة: | English |
| تدمد: | 2666-3864 2211-1247 |
| DOI: | 10.5167/uzh-208485 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45399fa94b4fee8c855621fec267e15b https://doi.org/10.5167/uzh-208485 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....45399fa94b4fee8c855621fec267e15b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26663864 22111247 |
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| DOI: | 10.5167/uzh-208485 |