Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease
| العنوان: | Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn’s disease |
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| المؤلفون: | Elena Xourgia, Antonios Gklavas, Christina Kapizioni, Evangelia Legaki, Ioannis Papaconstantinou, Maria Gazouli, George Karamanolis |
| المصدر: | World Journal of Gastrointestinal Pharmacology and Therapeutics |
| بيانات النشر: | Baishideng Publishing Group Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Crohn’s disease, 0301 basic medicine, Oncology, medicine.medical_specialty, Crohn's disease, Treatment response, business.industry, Mir 196a, MicroRNA, Disease, Case Control Study, medicine.disease, 3. Good health, Anti-TNF, 03 medical and health sciences, 030104 developmental biology, Internal medicine, microRNA, Medicine, Tumor necrosis factor alpha, Greek population, Polymorphisms, business, Biomarkers, miR-146 |
| الوصف: | AIM To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 polymorphisms and response to anti-TNF treatment in patients with Crohn’s disease (CD). METHODS One hundred seven patients with CD based on standard clinical, endoscopic, radiological, and pathological criteria were included in the study. They all received infliximab or adalimumab intravenously or subcutaneously at standard induction doses as per international guidelines. Clinical and biochemical response was assessed using the Harvey-Bradshaw index and CRP levels respectively. Endoscopic response was evaluated by ileocolonoscopy at week 12-20 of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and non-responders. Whole peripheral blood was extracted and genotyping was performed by PCR. RESULTS One hundred and seven patients were included in the study. Seventy two (67.3%) patients were classified as complete responders, 22 (20.5%) as partial while 13 (12.1%) were primary non-responders. No correlation was detected between response to anti-TNF agents and patients’ characteristics such as gender, age and disease duration while clinical and biochemical indexes used were associated with endoscopic response. Concerning prevalence of rs2910164, rs11614913, and rs188519172 polymorphisms of miR-146, miR-196a and miR-224 respectively no statistically important difference was found between complete, partial, and non-responders to anti-TNF treatment. Actually CC genotype of rs2910164 was not detected in any patient. Regarding rs113054794 of miR-221, normal CC genotype was the only one detected in all studied patients, suggesting this polymorphism is highly rare in the studied population. CONCLUSION No correlation is detected between studied polymorphisms and patients’ response to anti-TNF treatment. Polymorphism rs113054794 is not detected in our population. |
| تدمد: | 2150-5349 1130-5479 |
| DOI: | 10.4292/wjgpt.v8.i4.193 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c66fb18eb7ba0b8722ae18648175bf https://doi.org/10.4292/wjgpt.v8.i4.193 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....44c66fb18eb7ba0b8722ae18648175bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21505349 11305479 |
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| DOI: | 10.4292/wjgpt.v8.i4.193 |